Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 15/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 12/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17364394 | 0.99 | ADORA2B (0.44) | ADORA2BADORA2AADORA3ADORA1CHRM4 | |
| SCHEMBL17364390 | 0.93 | ADORA2B (0.43) | ADORA2BADORA2AADORA3ADORA1CHRM4 | |
| SCHEMBL1243077 | 0.93 | ADORA2B (0.43) | ADORA2BADORA2AADORA3ADORA1CHRM4 | |
| SCHEMBL1243256 | 0.91 | ADORA2B (0.42) | ADORA2BADORA2AADORA3ADORA1CHRM4 | |
| SCHEMBL1240743 | 0.91 | ADORA2B (0.43) | ADORA2BADORA2AADORA3ADORA1CHRM4 | |
| SCHEMBL1240971 | 0.91 | ADORA2B (0.41) | ADORA2BADORA2AADORA3ADORA1CHRM4 | |
| SCHEMBL1243733 | 0.90 | ADORA2B (0.44) | ADORA2BADORA2AADORA3ADORA1CHRM4 | |
| SCHEMBL17364391 | 0.88 | ADORA2B (0.46) | ADORA2BADORA2AADORA3ADORA1 | |
| SCHEMBL1241033 | 0.86 | ADORA2B (0.43) | ADORA2BADORA2AADORA3ADORA1CHRM4 | |
| SCHEMBL13757456 | 0.86 | ADORA2B (0.41) | ADORA2BADORA2AADORA3ADORA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9221821-B2 | Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds | Forest Laboratories Holdings, Limited (BM) | 2015-12-29 | — | — | US | disclosed |
| US-9221821-B2 | Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds | Forest Laboratories Holdings, Limited (BM) | 2015-12-29 | — | — | US | disclosed |