Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1735363 | 0.95 | KDM4E (0.48) | CTSLCTSSCTSKSYKCYP1A2 | |
| SCHEMBL13605452 | 0.92 | KDM4E (0.46) | CTSLCTSSCTSKSYKCYP2D6 | |
| SCHEMBL13605483 | 0.90 | HDAC3 (0.43) | CTSLCTSSCTSKSYKHDAC3 | |
| SCHEMBL1735216 | 0.90 | HDAC3 (0.43) | CTSLCTSSCTSKSYKHDAC3 | |
| SCHEMBL13605476 | 0.89 | SYK (0.45) | CTSLCTSSCTSKSYKCYP1A2 | |
| SCHEMBL13605459 | 0.86 | HDAC3 (0.41) | CTSLCTSSCTSKSYKCYP1A2 | |
| SCHEMBL13605294 | 0.81 | KDM4E (0.63) | CTSLCTSSCTSKSYKCYP1A2 | |
| SCHEMBL13605456 | 0.80 | HDAC3 (0.41) | SYKKDM4EHDAC3HDAC1HDAC2 | |
| SCHEMBL13605479 | 0.80 | HDAC3 (0.41) | SYKKDM4EHDAC3HDAC1HDAC2 | |
| SCHEMBL13605513 | 0.80 | HDAC3 (0.54) | SYKEPHX2CNR1HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928236-B1 | DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS | IRM LLC (BM) | 2011-11-23 | — | — | EP | claimed |