Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13605452 | 0.97 | KDM4E (0.46) | KDM4EPOLBKMT2ACDK1KDR | |
| Bicarbonate SCHEMBL1736482 | 0.95 | CTSL (0.46) | KDM4EPOLBCDK1KDRCTSL | |
| SCHEMBL13605483 | 0.86 | HDAC3 (0.43) | POLBKMT2ACDK1KDRCTSL | |
| SCHEMBL1735216 | 0.86 | HDAC3 (0.43) | POLBKMT2ACDK1KDRCTSL | |
| SCHEMBL13605476 | 0.86 | SYK (0.45) | POLBKMT2ACDK1KDRCTSL | |
| SCHEMBL13605294 | 0.85 | KDM4E (0.63) | KDM4ECTSLCTSSCTSKCHEK1 | |
| SCHEMBL13605459 | 0.83 | HDAC3 (0.41) | KDM4ECDK1KDRCTSLCTSS | |
| SCHEMBL5561766 | 0.81 | KDM4E (0.65) | KDM4EPOLBKMT2ACYP2D6CYP2C19 | |
| SCHEMBL787034 | 0.80 | KDM4E (0.67) | KDM4EPOLBKMT2ACYP2D6CYP2C19 | |
| SCHEMBL13605447 | 0.78 | ALDH1A1 (0.47) | KDM4EKMT2ACDK1KDRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928236-B1 | DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS | IRM LLC (BM) | 2011-11-23 | — | — | EP | claimed |