Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | FPR3 | P25089 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18870012 | 0.85 | KDM5B (0.37) | KDM4ELMNAALDH1A1THRBKDM5A | |
| SCHEMBL15995274 | 0.85 | KDM5B (0.37) | KDM4ELMNAALDH1A1THRBKDM5A | |
| SCHEMBL16293500 | 0.81 | KDM5B (0.36) | KDM4ELMNAALDH1A1KDM5AKDM2B | |
| SCHEMBL16006940 | 0.81 | KDM5B (0.36) | KDM4ELMNAALDH1A1KDM5AKDM2B | |
| SCHEMBL16006920 | 0.78 | KDM5B (0.34) | KDM4EALDH1A1KMT2AMEN1KDM5A | |
| SCHEMBL17984985 | 0.77 | KDM5B (0.38) | KDM4EKDM5AKDM2BKDM4CKDM5B | |
| SCHEMBL18831148 | 0.76 | KDM5B (0.36) | ALDH1A1KDM5AKDM2BKDM4CKDM5B | |
| SCHEMBL17984992 | 0.74 | HRH3 (0.38) | ALDH1A1 | |
| SCHEMBL16303322 | 0.74 | HRH3 (0.38) | ALDH1A1 | |
| SCHEMBL16305524 | 0.74 | KDM5B (0.36) | KMT2AMEN1KDM5AKDM2BKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9221801-B2 | Inhibitors of histone demethylases | EPITHERAPEUTICS APS (DK) | 2015-12-29 | — | — | US | disclosed |