Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | VCP | P55072 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1735180 | 0.82 | HDAC3 (0.48) | JAK2LMNAMAPK1TDP1KDR | |
| SCHEMBL13605643 | 0.74 | KDM4E (0.41) | JAK2KDR | |
| SCHEMBL655015 | 0.69 | AURKA (0.56) | JAK2CYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL16322967 | 0.69 | PDGFRB (0.55) | PDGFRBPDGFRACYP3A4CYP1A2LMNA | |
| SCHEMBL8596593 | 0.68 | HDAC4 (0.46) | KCNH2HRH3CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL656234 | 0.68 | AURKA (0.65) | JAK2PTK2CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL10971409 | 0.68 | HDAC3 (0.59) | LMNAMAPK1TDP1KDRALDH1A1 | |
| SCHEMBL13605322 | 0.68 | PLK1 (0.51) | KDR | |
| SCHEMBL28788981 | 0.67 | FYN (0.59) | PDGFRBPDGFRACYP3A4CYP1A2LMNA | |
| SCHEMBL10973669 | 0.67 | ADORA2A (0.53) | CYP3A4CYP1A2LMNAMAPK1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928236-B1 | DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS | IRM LLC (BM) | 2011-11-23 | — | — | EP | disclosed |