Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL123415 | 0.88 | MAPT (0.55) | MAPTHPGDKDM4EALDH1A1POLB | |
| SCHEMBL20851318 | 0.81 | MAPT (0.58) | MAPTHPGDKDM4EALDH1A1POLB | |
| SCHEMBL13155583 | 0.80 | ACACB (0.53) | MAPTHPGDKDM4EALDH1A1POLB | |
| SCHEMBL7329813 | 0.79 | NQO1 (0.67) | MAPTHPGDKDM4EALDH1A1POLB | |
| SCHEMBL2231003 | 0.79 | TSHR (0.50) | MAPTHPGDKDM4EALDH1A1POLB | |
| SCHEMBL3182331 | 0.79 | HPGD (0.66) | MAPTHPGDKDM4EALDH1A1POLB | |
| SCHEMBL2312172 | 0.77 | SCN4A (0.52) | MAPTHPGDKDM4EALDH1A1POLB | |
| SCHEMBL15114294 | 0.77 | LMNA (0.57) | MAPTHPGDKDM4EALDH1A1POLB | |
| SCHEMBL12306453 | 0.77 | MAPT (0.47) | MAPTHPGDKDM4EALDH1A1POLB | |
| SCHEMBL7528014 | 0.77 | MAPT (0.47) | MAPTHPGDKDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588451-B1 | PIPERIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF METABOLIC DISORDERS | BOEHRINGER INGELHEIM INT (DE) | 2015-12-30 | — | — | EP | disclosed |