Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 17/20 | 1.00 |
| ▸ | ALOX5AP | P20292 | 15/20 | 0.76 |
| ▸ | F2 | P00734 | 2/20 | 0.54 |
| ▸ | F10 | P00742 | 2/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15918040 | 0.87 | ALOX5AP (1.00) | FEN1ALOX5AP | |
| SCHEMBL15916448 | 0.78 | ALOX5AP (1.00) | FEN1ALOX5AP | |
| SCHEMBL17367693 | 0.76 | ALOX5AP (0.80) | FEN1ALOX5APF2F10PRSS1 | |
| SCHEMBL15917876 | 0.75 | FEN1 (0.84) | FEN1ALOX5AP | |
| SCHEMBL15915491 | 0.72 | ALOX5AP (0.73) | FEN1ALOX5AP | |
| SCHEMBL15916676 | 0.71 | ALOX5AP (1.00) | FEN1ALOX5AP | |
| SCHEMBL15917352 | 0.70 | ALOX5AP (1.00) | FEN1ALOX5AP | |
| SCHEMBL15917182 | 0.69 | ALOX5AP (1.00) | FEN1ALOX5AP | |
| SCHEMBL15915836 | 0.69 | ALOX5AP (0.60) | FEN1ALOX5AP | |
| SCHEMBL17367659 | 0.69 | FEN1 (1.00) | FEN1ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9745328-B2 | Flap modulators | JANSSEN PHARMACEUTICA NV (BE) | 2017-08-29 | — | — | US | disclosed |
| US-9745328-B2 | Flap modulators | JANSSEN PHARMACEUTICA NV (BE) | 2017-08-29 | — | — | US | disclosed |
| US-20150376212-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-31 | — | — | US | disclosed |
| US-20150376212-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150376212-A1 | FLAP MODULATORS | FEN1, PGF, TBXA2R | FEN1 1/4885ALOX5AP 95/4885F2 275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.