Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 5/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1736733 | 0.93 | LMNA (0.54) | LMNAMAPTTP53SMN1; SMN2HTT | |
| SCHEMBL1736731 | 0.93 | LMNA (0.54) | LMNAMAPTTP53SMN1; SMN2HTT | |
| SCHEMBL1734775 | 0.92 | MAPT (0.52) | LMNAMAPTTP53SMN1; SMN2HTT | |
| SCHEMBL1735837 | 0.92 | MAPT (0.52) | LMNAMAPTTP53SMN1; SMN2HTT | |
| SCHEMBL1734779 | 0.92 | MAPT (0.52) | LMNAMAPTTP53SMN1; SMN2HTT | |
| SCHEMBL1735711 | 0.88 | LMNA (0.51) | LMNAMAPTTP53SMN1; SMN2HTT | |
| SCHEMBL1734790 | 0.88 | LMNA (0.46) | LMNAMAPTTP53SMN1; SMN2HTT | |
| SCHEMBL1734791 | 0.88 | LMNA (0.46) | LMNAMAPTTP53SMN1; SMN2HTT | |
| SCHEMBL1735709 | 0.88 | LMNA (0.51) | LMNAMAPTTP53SMN1; SMN2HTT | |
| SCHEMBL1734767 | 0.87 | MAPT (0.44) | LMNAMAPTTP53SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142533-B1 | IMIDAZOLIDINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-11-16 | — | — | EP | claimed |
| WO-2011069003-A3 | METHODS AND SYSTEMS FOR THE TREATMENT OF ANXIETY DISORDERS AND DISORDERS WITH PSYCHOTIC FEATURES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-10-27 | — | — | WO | claimed |