Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.44 |
| ▸ | QPCT | Q16769 | 1/20 | 0.44 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.44 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL164101 | 0.83 | CYP11B1 (0.47) | CYP11B1CYP11B2CYP19A1CYP1A2POLB | |
| SCHEMBL21500650 | 0.83 | NAMPT (0.56) | NAMPTCYP11B1CYP11B2CYP19A1CYP1A2 | |
| SCHEMBL21500639 | 0.83 | NAMPT (0.56) | NAMPTCYP11B1CYP11B2CYP19A1CYP1A2 | |
| SCHEMBL159804 | 0.82 | CYP11B1 (0.47) | CYP11B1CYP11B2CYP17A1 | |
| SCHEMBL21500648 | 0.81 | NAMPT (0.55) | NAMPTCYP11B1CYP11B2CYP19A1CYP1A2 | |
| SCHEMBL22399251 | 0.81 | NAMPT (0.58) | NAMPTCYP19A1POLB | |
| SCHEMBL19742865 | 0.80 | CYP11B1 (0.68) | CYP11B1CYP11B2CYP19A1CYP1A2POLB | |
| SCHEMBL22399257 | 0.80 | NAMPT (0.51) | NAMPTCYP11B1CYP19A1CYP3A4CYP17A1 | |
| SCHEMBL22399266 | 0.77 | CYP11B1 (0.51) | CYP11B1CYP11B2CYP19A1CYP1A2POLB | |
| SCHEMBL21500662 | 0.77 | NAMPT (0.49) | NAMPTCYP11B1CYP11B2CYP19A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611804-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | Forma TM, LLC. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012031197-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | FORMA THERAPEUTICS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |