Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 8/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | BRPF1 | P55201 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17373751 | 0.80 | IRAK4 (0.51) | PIM1PIM3IRAK4MAPTBRPF1 | |
| SCHEMBL16898801 | 0.80 | IRAK4 (0.54) | PIM1PIM3IRAK4MAPTBRPF1 | |
| SCHEMBL23293468 | 0.78 | CSF1R (0.56) | PIM1PIM3IRAK4MAPTALDH1A1 | |
| SCHEMBL31157977 | 0.78 | CSF1R (0.56) | PIM1PIM3IRAK4MAPTALDH1A1 | |
| SCHEMBL17373869 | 0.78 | PIM1 (0.48) | PIM1PIM3IRAK4MAPTBRPF1 | |
| SCHEMBL20623368 | 0.73 | PIM1 (0.52) | PIM1PIM3IRAK4MAPTALDH1A1 | |
| SCHEMBL20598735 | 0.73 | NTRK1 (0.57) | PIM1PIM3IRAK4MAPTALDH1A1 | |
| SCHEMBL30501448 | 0.73 | NTRK1 (0.57) | PIM1PIM3IRAK4MAPTALDH1A1 | |
| SCHEMBL20598482 | 0.73 | PIM1 (0.51) | PIM1PIM3IRAK4MAPTALDH1A1 | |
| SCHEMBL30501501 | 0.73 | PIM1 (0.51) | PIM1PIM3IRAK4MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170152263-A1 | Substituted Indazole Compounds as IRAK4 Inhibitors | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2017-06-01 | — | — | US | disclosed |
| EP-3157521-A1 | SUBSTITUTED INDAZOLE COMPOUNDS AS IRAK4 INHIBITORS | Aurigene Discovery Technologies Limited (IN) | 2017-04-26 | — | — | EP | disclosed |
| WO-2015193846-A1 | SUBSTITUTED INDAZOLE COMPOUNDS AS IRAK4 INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2015-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170152263-A1 | Substituted Indazole Compounds as IRAK4 Inhibitors | IRAK4, IRAK3, IRAK2 | PIM1 88/4885PIM3 111/4885IRAK4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.