Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | PDE4A | P27815 | 6/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | CASP7 | P55210 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30869219 | 1.00 | KDM4E (0.54) | KDM4EALDH1A1LMNAHSD17B10PDE4A | |
| SCHEMBL3305218 | 0.89 | PDE4A (0.45) | KDM4EALDH1A1LMNAHSD17B10PDE4A | |
| SCHEMBL3303826 | 0.88 | PDE4A (0.47) | KDM4EALDH1A1LMNAHSD17B10PDE4A | |
| SCHEMBL30869223 | 0.85 | PDE4A (0.62) | KDM4EALDH1A1LMNAHSD17B10PDE4A | |
| SCHEMBL18986757 | 0.85 | PDE4A (0.62) | KDM4EALDH1A1LMNAHSD17B10PDE4A | |
| SCHEMBL30869218 | 0.82 | PDE4A (0.38) | KDM4EALDH1A1LMNAHSD17B10PDE4A | |
| SCHEMBL18987057 | 0.82 | PDE4A (0.38) | KDM4EALDH1A1LMNAHSD17B10PDE4A | |
| SCHEMBL30869216 | 0.82 | PDE4A (0.38) | KDM4EALDH1A1LMNAHSD17B10PDE4A | |
| SCHEMBL3302030 | 0.82 | PDE4A (0.39) | KDM4EALDH1A1LMNAHSD17B10PDE4A | |
| SCHEMBL3304082 | 0.81 | PDE4A (0.41) | KDM4EALDH1A1LMNAHSD17B10PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260035383-A1 | METHODS FOR THE PREPARATION OF 1,3-BENZODIOXOLE HETEROCYCLIC COMPOUNDS | UNION THERAPEUTICS AS (DK) | 2026-02-05 | — | — | US | disclosed |
| EP-3642210-B1 | METHODS FOR THE PREPARATION OF 1,3-BENZODIOXOLE HETEROCYCLIC COMPOUNDS | UNION THERAPEUTICS AS (DK) | 2024-11-13 | — | — | EP | disclosed |
| US-12084457-B2 | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds | UNION therapeutics A/S (DK) | 2024-09-10 | — | — | US | disclosed |
| EP-3390407-B1 | METHODS FOR THE PREPARATION OF 1,3-BENZODIOXOLE HETEROCYCLIC COMPOUNDS | UNION THERAPEUTICS AS (DK) | 2023-10-11 | — | — | EP | disclosed |
| US-20230073362-A1 | METHODS FOR THE PREPARATION OF 1,3-BENZODIOXOLE HETEROCYCLIC COMPOUNDS | UNION therapeutics A/S (DK) | 2023-03-09 | — | — | US | disclosed |
| US-11370799-B2 | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds | UNION therapeutics A/S (DK) | 2022-06-28 | — | — | US | disclosed |
| US-20220162227-A1 | METHODS FOR THE PREPARATION OF 1,3-BENZODIOXOLE HETEROCYCLIC COMPOUNDS | UNION therapeutics A/S (DK) | 2022-05-26 | — | — | US | disclosed |
| US-11220514-B2 | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds | UNION therapeutics A/S (DK) | 2022-01-11 | — | — | US | disclosed |
| US-20210147440-A1 | METHODS FOR THE PREPARATION OF 1,3-BENZODIOXOLE HETEROCYCLIC COMPOUNDS | UNION therapeutics A/S (DK) | 2021-05-20 | — | — | US | disclosed |
| US-20200262842-A1 | METHODS FOR THE PREPARATION OF 1,3-BENZODIOXOLE HETEROCYCLIC COMPOUNDS | UNION therapeutics A/S (DK) | 2020-08-20 | — | — | US | disclosed |
| EP-3642210-A1 | METHODS FOR THE PREPARATION OF 1,3-BENZODIOXOLE HETEROCYCLIC COMPOUNDS | Leo Pharma A/S (DK) | 2020-04-29 | — | — | EP | disclosed |
| WO-2018234299-A1 | METHODS FOR THE PREPARATION OF 1,3-BENZODIOXOLE HETEROCYCLIC COMPOUNDS | LEO PHARMA A/S (DK) | 2018-12-27 | — | — | WO | disclosed |
| EP-3390407-A1 | METHODS FOR THE PREPARATION OF 1,3-BENZODIOXOLE HETEROCYCLIC COMPOUNDS | Leo Pharma A/S (DK) | 2018-10-24 | — | — | EP | disclosed |
| EP-3157930-B1 | METHODS FOR THE PREPARATION OF 1,3-BENZODIOXOLE HETEROCYCLIC COMPOUNDS | LEO PHARMA AS (DK) | 2018-10-17 | — | — | EP | disclosed |
| US-9908894-B2 | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds | LEO PHARMA A/S (DK) | 2018-03-06 | — | — | US | disclosed |
| WO-2017103058-A1 | METHODS FOR THE PREPARATION OF 1,3-BENZODIOXOLE HETEROCYCLIC COMPOUNDS | LEO PHARMA A/S (DK) | 2017-06-22 | — | — | WO | disclosed |
| US-20170137438-A1 | METHODS FOR THE PREPARATION OF 1,3-BENZODIOXOLE HETEROCYCLIC COMPOUNDS | UNION therapeutics A/S (DK) | 2017-05-18 | — | — | US | disclosed |
| EP-3157930-A2 | METHODS FOR THE PREPARATION OF 1,3-BENZODIOXOLE HETEROCYCLIC COMPOUNDS | Leo Pharma A/S (DK) | 2017-04-26 | — | — | EP | disclosed |
| WO-2015197534-A2 | METHODS FOR THE PREPARATION OF 1,3-BENZODIOXOLE HETEROCYCLIC COMPOUNDS | LEO PHARMA A/S (DK) | 2015-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200262842-A1 | METHODS FOR THE PREPARATION OF 1,3-BENZODIOXOLE HETEROCYCLIC COMPOUNDS | PDE4B, PDE4A, PDE4C | KDM4E 313/4885ALDH1A1 687/4885LMNA 1790/4885 |
| US-20210147440-A1 | METHODS FOR THE PREPARATION OF 1,3-BENZODIOXOLE HETEROCYCLIC COMPOUNDS | PDE4B, PDE4A, PDE3B | KDM4E 480/4885ALDH1A1 304/4885LMNA 1766/4885 |
| US-20230073362-A1 | METHODS FOR THE PREPARATION OF 1,3-BENZODIOXOLE HETEROCYCLIC COMPOUNDS | PDE4B, PDE4A, PDE3B | KDM4E 391/4885ALDH1A1 618/4885LMNA 1734/4885 |
| US-11220514-B2 | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds | PDE4B, PDE4A, PDE3B | KDM4E 480/4885ALDH1A1 304/4885LMNA 1766/4885 |
| US-20170137438-A1 | METHODS FOR THE PREPARATION OF 1,3-BENZODIOXOLE HETEROCYCLIC COMPOUNDS | PDE4B, PDE4A, PDE3B | KDM4E 391/4885ALDH1A1 618/4885LMNA 1734/4885 |
| US-12084457-B2 | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds | PDE4B, PDE4A, PDE4C | KDM4E 311/4885ALDH1A1 719/4885LMNA 1880/4885 |
| US-20220162227-A1 | METHODS FOR THE PREPARATION OF 1,3-BENZODIOXOLE HETEROCYCLIC COMPOUNDS | PDE4B, PDE4A, PDE4C | KDM4E 401/4885ALDH1A1 748/4885LMNA 1885/4885 |
| US-20260035383-A1 | METHODS FOR THE PREPARATION OF 1,3-BENZODIOXOLE HETEROCYCLIC COMPOUNDS | NOX4, PDE3B, CBR1 | KDM4E 876/4885ALDH1A1 59/4885LMNA 2199/4885 |
| US-11370799-B2 | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds | PDE4B, PDE4A, PDE4C | KDM4E 313/4885ALDH1A1 687/4885LMNA 1790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.