SCHEMBL1737540

SCHEMBL1737540

Cc1c(C)n(C)c2c(COc3ccc(Cl)c(Cl)c3)nccc12

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 2/20 0.38
MAPT P10636 2/20 0.37
POLB P06746 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
MAOB P27338 1/20 0.37
KDM4E B2RXH2 5/20 0.36
ALDH1A1 P00352 4/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
DYRK1A Q13627 2/20 0.35
GAA P10253 1/20 0.34
MAPK1 P28482 1/20 0.34
NPC1 O15118 2/20 0.34
RAB9A P51151 2/20 0.34
MAOA P21397 1/20 0.34
BCHE P06276 1/20 0.34
ACHE P22303 1/20 0.34
GRM5 P41594 1/20 0.34
HPGD P15428 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1735398 0.99 PTGDR2 (0.37) PTGDR2MAPTPOLBTDP1L3MBTL1
SCHEMBL1736127 0.86 DYRK1A (0.40) PTGDR2MAPTPOLBTDP1L3MBTL1
SCHEMBL1737518 0.86 MAOB (0.40) MAPTTDP1L3MBTL1MAOBKDM4E
SCHEMBL1737474 0.86 DYRK1A (0.38) PTGDR2MAPTPOLBTDP1L3MBTL1
Hydrochloric Acid SCHEMBL1736588 0.85 DYRK1A (0.39) PTGDR2MAPTPOLBTDP1L3MBTL1
Hydrochloric Acid SCHEMBL1735591 0.85 MAOB (0.39) MAPTTDP1L3MBTL1MAOBKDM4E
Hydrochloric Acid SCHEMBL1737703 0.85 DYRK1A (0.37) PTGDR2MAPTPOLBTDP1L3MBTL1
SCHEMBL1736200 0.84 TSHR (0.36) PTGDR2MAPTPOLBTDP1L3MBTL1
Hydrochloric Acid SCHEMBL1736557 0.83 KMT2A (0.35) PTGDR2MAPTPOLBTDP1L3MBTL1
SCHEMBL1737469 0.82 DYRK1A (0.50) PTGDR2MAPTPOLBTDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1784404-B1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORP (KR) 2011-11-16 EP claimed
US-20110263306-A1 COMPUTER SYSTEM AND PROGRAM NAMCO BANDAI GAMES INC. (JP) 2011-10-27 US claimed