Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | HPGD | P15428 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.35 |
| ▸ | TSHR | P16473 | 5/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17375766 | 0.94 | KDM4E (0.32) | KDM4EALDH1A1HPGDMAPTGLA | |
| SCHEMBL17375788 | 0.85 | KCNK3 (0.35) | KDM4EALDH1A1HPGDMAPTGLA | |
| SCHEMBL15826519 | 0.77 | GPR84 (0.47) | GPR84 | |
| SCHEMBL15825896 | 0.71 | GPR84 (0.35) | GPR84 | |
| SCHEMBL568334 | 0.70 | MAOB (0.36) | KDM4EALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL15826037 | 0.70 | GPR84 (0.37) | GPR84 | |
| SCHEMBL15825884 | 0.69 | GPR84 (0.42) | GPR84 | |
| SCHEMBL15822296 | 0.69 | GPR84 (0.48) | GPR84 | |
| SCHEMBL15825410 | 0.69 | GPR84 (0.53) | GPR84 | |
| SCHEMBL15824547 | 0.69 | GPR84 (0.50) | GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3710004-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR USE IN THE TREATMENT OF FIBROTIC DISEASES | Galapagos NV (BE) | 2020-09-23 | — | — | EP | claimed |
| CN-111343986-A | Compounds and pharmaceutical compositions thereof for the treatment of fibrotic diseases | 加拉帕戈斯股份有限公司 | 2020-06-26 | — | — | CN | claimed |
| WO-2015197550-A1 | NOVEL DIHYDROPYRIDOISOQUINOLINONES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2015-12-30 | — | — | WO | claimed |
| EP-3710004-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR USE IN THE TREATMENT OF FIBROTIC DISEASES | Galapagos NV (BE) | 2020-09-23 | — | — | EP | disclosed |
| CN-111343986-A | Compounds and pharmaceutical compositions thereof for the treatment of fibrotic diseases | 加拉帕戈斯股份有限公司 | 2020-06-26 | — | — | CN | disclosed |
| WO-2015197550-A1 | NOVEL DIHYDROPYRIDOISOQUINOLINONES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2015-12-30 | — | — | WO | disclosed |