Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 20/20 | 0.64 |
| ▸ | WDR77 | Q9BQA1 | 18/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17377139 | 1.00 | PRMT5 (0.64) | PRMT5WDR77KCNH2 | |
| SCHEMBL19170600 | 0.95 | PRMT5 (0.63) | PRMT5WDR77KCNH2 | |
| SCHEMBL15825525 | 0.88 | PRMT5 (0.83) | PRMT5WDR77KCNH2 | |
| SCHEMBL32617556 | 0.88 | PRMT5 (0.83) | PRMT5WDR77KCNH2 | |
| SCHEMBL17308663 | 0.88 | PRMT5 (0.83) | PRMT5WDR77KCNH2 | |
| SCHEMBL15825524 | 0.88 | PRMT5 (0.83) | PRMT5WDR77KCNH2 | |
| SCHEMBL19171127 | 0.87 | PRMT5 (0.76) | PRMT5WDR77 | |
| SCHEMBL17377022 | 0.87 | PRMT5 (0.69) | PRMT5WDR77KCNH2 | |
| SCHEMBL19171198 | 0.87 | PRMT5 (0.69) | PRMT5WDR77KCNH2 | |
| SCHEMBL17377023 | 0.87 | PRMT5 (0.69) | PRMT5WDR77KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170210751-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2017-07-27 | — | — | US | disclosed |
| EP-3160466-A2 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2017-05-03 | — | — | EP | disclosed |
| WO-2015200677-A2 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2015-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170210751-A1 | PRMT5 INHIBITORS AND USES THEREOF | PRMT5, PRMT1, PRMT6 | PRMT5 1/4885WDR77 68/4885KCNH2 3717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.