SCHEMBL1737773

SCHEMBL1737773

Cc1c(C)n(Cc2ccc(Cl)cc2)c2c(-c3ccccc3)nccc12

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FABP4 P15090 1/20 0.44
MCL1 Q07820 3/20 0.44
ALDH1A1 P00352 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
KDM4E B2RXH2 1/20 0.43
POLB P06746 1/20 0.43
MAPT P10636 1/20 0.43
CCNA2 P20248 1/20 0.42
CDK2 P24941 1/20 0.42
LMNA P02545 2/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
HTT P42858 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
PTGDR2 Q9Y5Y4 1/20 0.41
CNR2 P34972 2/20 0.40
DRD2 P14416 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1735597 0.99 FABP4 (0.43) FABP4MCL1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL1736273 0.95 FABP4 (0.47) FABP4MCL1ALDH1A1KDM4EPOLB
Hydrochloric Acid SCHEMBL1736505 0.94 FABP4 (0.46) FABP4MCL1ALDH1A1KDM4EPOLB
SCHEMBL1738530 0.94 KDM4E (0.46) FABP4MCL1ALDH1A1SMN1; SMN2KDM4E
Hydrochloric Acid SCHEMBL1736616 0.92 KDM4E (0.44) FABP4MCL1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL1737107 0.92 FABP4 (0.51) FABP4MCL1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL1736036 0.91 MCL1 (0.53) FABP4MCL1ALDH1A1SMN1; SMN2KDM4E
Hydrochloric Acid SCHEMBL1736953 0.91 FABP4 (0.50) FABP4MCL1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL1736461 0.90 MCL1 (0.46) FABP4MCL1SMN1; SMN2KDM4EPOLB
SCHEMBL1738026 0.90 MCL1 (0.46) FABP4MCL1SMN1; SMN2KDM4EPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1784404-B1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORP (KR) 2011-11-16 EP claimed
US-20110263306-A1 COMPUTER SYSTEM AND PROGRAM NAMCO BANDAI GAMES INC. (JP) 2011-10-27 US claimed
EP-1784404-A4 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORP (KR) 2009-09-09 EP claimed
JP-2008511621-A 2008-04-17 JP claimed
EP-1784404-A1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF Yuhan Corporation (KR) 2007-05-16 EP claimed
WO-2006025716-A1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORPORATION (KR) 2006-03-09 WO claimed