SCHEMBL1737967

SCHEMBL1737967

COc1cccc(CC(c2nccc3c(C)c(C)[nH]c23)N(C)c2ccc(F)cc2)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 3/20 0.38
DYRK1A Q13627 1/20 0.36
MAOB P27338 2/20 0.35
QPCT Q16769 1/20 0.35
TAAR1 Q96RJ0 2/20 0.34
KDM4C Q9H3R0 1/20 0.33
KDM5B Q9UGL1 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
MAPK13 O15264 1/20 0.33
PTGS1 P23219 1/20 0.33
MAPK12 P53778 1/20 0.33
MAPK11 Q15759 1/20 0.33
MAPK14 Q16539 1/20 0.33
ABCB1 P08183 1/20 0.33
HTR1B P28222 1/20 0.32
SLC2A1 P11166 1/20 0.32
TSHR P16473 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1737948 0.99 ROCK2 (0.37) ROCK2DYRK1AMAOBQPCTTAAR1
SCHEMBL1739207 0.90 CYP1A2 (0.35) ROCK2TAAR1CYP1A2CYP3A4CYP2C9
SCHEMBL1738883 0.89 DYRK1A (0.36) DYRK1ACYP1A2CYP3A4CYP2C9CYP2C19
Hydrochloric Acid SCHEMBL1737512 0.89 CYP1A2 (0.35) ROCK2TAAR1CYP1A2CYP3A4CYP2C9
SCHEMBL1739718 0.89 CSF1R (0.37) KDM5BCYP1A2CYP3A4CYP2C9CYP2C19
Hydrochloric Acid SCHEMBL1738258 0.88 CSF1R (0.36) KDM5BCYP1A2CYP3A4CYP2C9CYP2C19
Hydrochloric Acid SCHEMBL1735351 0.88 DYRK1A (0.36) DYRK1ACYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL1737675 0.87 CYP1A2 (0.35) MAOBCYP1A2CYP3A4CYP2C9CYP2C19
Hydrochloric Acid SCHEMBL1737714 0.86 CYP1A2 (0.34) CYP1A2CYP3A4CYP2C9CYP2C19MAPK14
SCHEMBL1736209 0.86 CYP1A2 (0.34) CYP1A2CYP3A4CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1784404-B1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORP (KR) 2011-11-16 EP claimed
US-20110263306-A1 COMPUTER SYSTEM AND PROGRAM NAMCO BANDAI GAMES INC. (JP) 2011-10-27 US claimed