Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 2/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MLLT1 | Q03111 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | SCD | O00767 | 2/20 | 0.43 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18617096 | 1.00 | RAB9A (0.53) | RAB9ANPC1S1PR1MAPTLMNA | |
| SCHEMBL17374433 | 1.00 | RAB9A (0.53) | RAB9ANPC1S1PR1MAPTLMNA | |
| SCHEMBL17374483 | 1.00 | RAB9A (0.53) | RAB9ANPC1S1PR1MAPTLMNA | |
| SCHEMBL17933873 | 1.00 | RAB9A (0.53) | RAB9ANPC1S1PR1MAPTLMNA | |
| SCHEMBL17374432 | 1.00 | RAB9A (0.53) | RAB9ANPC1S1PR1MAPTLMNA | |
| SCHEMBL17374486 | 1.00 | RAB9A (0.53) | RAB9ANPC1S1PR1MAPTLMNA | |
| SCHEMBL20200077 | 0.93 | RAB9A (0.54) | RAB9ANPC1S1PR1MAPTLMNA | |
| SCHEMBL20200079 | 0.93 | RAB9A (0.54) | RAB9ANPC1S1PR1MAPTLMNA | |
| SCHEMBL20200060 | 0.84 | RAB9A (0.54) | RAB9ANPC1S1PR1MAPTLMNA | |
| SCHEMBL20200072 | 0.84 | RAB9A (0.54) | RAB9ANPC1S1PR1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015196071-A9 | COMPOUNDS, COMPOSITIONS AND METHODS OF INCREASING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2016-02-18 | — | — | WO | disclosed |
| WO-2015196071-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF INCREASING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2015-12-23 | — | — | WO | disclosed |