Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGA | O60502 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.31 |
| ▸ | PAK1 | Q13153 | 4/20 | 0.31 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19245620 | 1.00 | OGA (0.35) | OGASMYD3PAK1PKN1ACHE | |
| SCHEMBL17500144 | 0.81 | SMYD3 (0.36) | OGASMYD3PAK1PKN1ACHE | |
| SCHEMBL17500142 | 0.81 | SMYD3 (0.36) | OGASMYD3PAK1PKN1ACHE | |
| SCHEMBL20200051 | 0.79 | OGA (0.37) | OGASMYD3PAK1ACHE | |
| SCHEMBL18581843 | 0.78 | OGA (0.45) | OGAPAK1PKN1ACHE | |
| Hydrochloric Acid SCHEMBL17374363 | 0.78 | OGA (0.37) | OGASMYD3ACHE | |
| Hydrochloric Acid SCHEMBL17374365 | 0.78 | OGA (0.37) | OGASMYD3ACHE | |
| SCHEMBL26928851 | 0.77 | OGA (0.40) | OGAPAK1ACHE | |
| SCHEMBL17374168 | 0.74 | KMT2A (0.48) | — | |
| SCHEMBL17374170 | 0.74 | KMT2A (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017040606-A1 | ISOXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PULMONARY DISEASES AND DISORDERS | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2017-03-09 | — | — | WO | disclosed |
| WO-2016115090-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR INCREASING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2016-07-21 | — | — | WO | disclosed |
| WO-2015196071-A9 | COMPOUNDS, COMPOSITIONS AND METHODS OF INCREASING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2016-02-18 | — | — | WO | disclosed |
| WO-2015196071-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF INCREASING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2015-12-23 | — | — | WO | disclosed |