Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | OGA | O60502 | 1/20 | 0.34 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.32 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17500142 | 1.00 | SMYD3 (0.36) | SMYD3HSP90AA1HSP90AB1ACHEMEN1 | |
| SCHEMBL17374168 | 0.82 | KMT2A (0.48) | KMT2A | |
| SCHEMBL17374170 | 0.82 | KMT2A (0.48) | KMT2A | |
| SCHEMBL17381653 | 0.81 | OGA (0.35) | SMYD3ACHEOGAPAK1PKN1 | |
| SCHEMBL19245620 | 0.81 | OGA (0.35) | SMYD3ACHEOGAPAK1PKN1 | |
| SCHEMBL26601146 | 0.79 | SMYD3 (0.37) | SMYD3ACHEMEN1KMT2AOPRK1 | |
| SCHEMBL26601141 | 0.79 | SMYD3 (0.37) | SMYD3ACHEMEN1KMT2AOPRK1 | |
| SCHEMBL17500118 | 0.77 | SMYD3 (0.36) | SMYD3ACHEOPRK1LMNA | |
| SCHEMBL17500115 | 0.77 | SMYD3 (0.36) | SMYD3ACHEOPRK1LMNA | |
| SCHEMBL17374222 | 0.76 | RAB9A (0.55) | KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015196071-A9 | COMPOUNDS, COMPOSITIONS AND METHODS OF INCREASING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2016-02-18 | — | — | WO | disclosed |