Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.50 |
| ▸ | RAB9A | P51151 | 7/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 2/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | MLLT1 | Q03111 | 4/20 | 0.44 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17381661 | 1.00 | NPC1 (0.50) | NPC1RAB9AS1PR1FAAHUSP30 | |
| SCHEMBL17374183 | 0.87 | RAB9A (0.55) | NPC1RAB9AS1PR1FAAHUSP30 | |
| SCHEMBL17374428 | 0.87 | RAB9A (0.55) | NPC1RAB9AS1PR1FAAHUSP30 | |
| SCHEMBL17374180 | 0.87 | RAB9A (0.55) | NPC1RAB9AS1PR1FAAHUSP30 | |
| SCHEMBL20200063 | 0.86 | RAB9A (0.54) | NPC1RAB9AS1PR1FAAHUSP30 | |
| SCHEMBL20200054 | 0.86 | RAB9A (0.54) | NPC1RAB9AS1PR1FAAHUSP30 | |
| SCHEMBL19239573 | 0.86 | RAB9A (0.45) | NPC1RAB9AS1PR1FAAHUSP30 | |
| SCHEMBL17374593 | 0.86 | RAB9A (0.45) | NPC1RAB9AS1PR1FAAHUSP30 | |
| SCHEMBL17374592 | 0.86 | RAB9A (0.45) | NPC1RAB9AS1PR1FAAHUSP30 | |
| SCHEMBL17374601 | 0.85 | RAB9A (0.53) | NPC1RAB9AS1PR1FAAHUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015196071-A9 | COMPOUNDS, COMPOSITIONS AND METHODS OF INCREASING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2016-02-18 | — | — | WO | disclosed |
| WO-2015196071-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF INCREASING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2015-12-23 | — | — | WO | disclosed |