Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.42 |
| ▸ | BRD9 | Q9H8M2 | 12/20 | 0.40 |
| ▸ | BRD4 | O60885 | 4/20 | 0.40 |
| ▸ | BRPF1 | P55201 | 3/20 | 0.40 |
| ▸ | BRD7 | Q9NPI1 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | WEE1 | P30291 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1740171 | 1.00 | ROCK2 (0.42) | ROCK2BRD9BRD4BRPF1BRD7 | |
| SCHEMBL12295015 | 1.00 | ROCK2 (0.42) | ROCK2BRD9BRD4BRPF1BRD7 | |
| SCHEMBL1738777 | 1.00 | ROCK2 (0.42) | ROCK2BRD9BRD4BRPF1BRD7 | |
| SCHEMBL12295017 | 1.00 | ROCK2 (0.42) | ROCK2BRD9BRD4BRPF1BRD7 | |
| SCHEMBL12295013 | 1.00 | ROCK2 (0.42) | ROCK2BRD9BRD4BRPF1BRD7 | |
| SCHEMBL1738670 | 0.91 | ROCK2 (0.40) | ROCK2BRD9BRD4BRPF1BRD7 | |
| SCHEMBL1737753 | 0.91 | ROCK2 (0.40) | ROCK2BRD9BRD4BRPF1BRD7 | |
| SCHEMBL1737725 | 0.91 | ROCK2 (0.40) | ROCK2BRD9BRD4BRPF1BRD7 | |
| SCHEMBL12327970 | 0.91 | ROCK2 (0.41) | ROCK2HTR2C | |
| SCHEMBL12327971 | 0.91 | ROCK2 (0.41) | ROCK2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1727794-B1 | NOVEL BENZYL(IDENE)-LACTAM DERIVATIVES | PFIZER PROD INC (US) | 2011-11-16 | — | — | EP | claimed |
| US-20110263484-A1 | SINGLE CHAIN FC TYPE III INTERFERONS AND METHODS OF USING SAME | ZYMOGENETICS, INC. | 2011-10-27 | — | — | US | claimed |
| US-7479559-B2 | 3-[-2-(Piperazin-1-yl)benzyl]pyrrolidin-2-one derivatives; antidepressants, anxiolytic agents; obsessive compulsive disorder, psychological disorders, phobias; 5-HT1 agonist or antagonists; side effect reduction, in particular cardiac QTc prolongation; hydrogenation | PFIZER INC. (US) | 2009-01-20 | — | — | US | claimed |
| WO-2007026219-A2 | COMBINATIONS OF A 5-HT1B ANTAGONIST WITH A NORADRENALIN RE-UPTAKE INHIBITOR OR A SEROTONIN NORADRENALIN REUTAKE INHIBITOR FOR TREATING CNS CONDITIONS | PFIZER PRODUCTS INC. (US) | 2007-03-08 | — | — | WO | claimed |
| WO-2007012964-A1 | PREPARATION OF ALKYLPIPERAZINYLPHENYL COMPOUNDS BY CLASSICAL RESOLUTION | PFIZER PRODUCTS INC. (US) | 2007-02-01 | — | — | WO | claimed |
| EP-1836164-B1 | 11C-LABELED BENZYL-LACTAM COMPOUNDS AND THEIR USE AS IMAGING AGENTS | GE HEALTHCARE LTD (GB) | 2011-08-24 | — | — | EP | disclosed |
| WO-2007026219-A2 | COMBINATIONS OF A 5-HT1B ANTAGONIST WITH A NORADRENALIN RE-UPTAKE INHIBITOR OR A SEROTONIN NORADRENALIN REUTAKE INHIBITOR FOR TREATING CNS CONDITIONS | PFIZER PRODUCTS INC. (US) | 2007-03-08 | — | — | WO | disclosed |
| WO-2007026224-A2 | 5-HT1B ANTAGONIST COMPOSITION FOR DEPRESSION, ANXIETY AND COGNITION | PFIZER PRODUCTS INC. (US) | 2007-03-08 | — | — | WO | disclosed |
| WO-2007012964-A1 | PREPARATION OF ALKYLPIPERAZINYLPHENYL COMPOUNDS BY CLASSICAL RESOLUTION | PFIZER PRODUCTS INC. (US) | 2007-02-01 | — | — | WO | disclosed |