Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 5/20 | 0.79 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.76 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.76 |
| ▸ | PAK1 | Q13153 | 10/20 | 0.61 |
| ▸ | PAK4 | O96013 | 3/20 | 0.61 |
| ▸ | SIK1 | P57059 | 1/20 | 0.58 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.58 |
| ▸ | MET | P08581 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1457104 | 0.89 | PDPK1 (1.00) | PDPK1PIK3CDPIK3CAPAK1PAK4 | |
| SCHEMBL1456620 | 0.86 | PDPK1 (1.00) | PDPK1PIK3CDPIK3CAPAK1PAK4 | |
| SCHEMBL2426811 | 0.84 | PDPK1 (0.90) | PDPK1PIK3CDPIK3CAPAK1PAK4 | |
| SCHEMBL1913485 | 0.82 | PDPK1 (0.71) | PDPK1PIK3CDPIK3CAPAK1PAK4 | |
| SCHEMBL2423125 | 0.80 | PDPK1 (0.81) | PDPK1PIK3CDPIK3CAPAK1PAK4 | |
| SCHEMBL1456803 | 0.79 | PDPK1 (0.80) | PDPK1PIK3CDPIK3CAPAK1PAK4 | |
| SCHEMBL1456037 | 0.79 | PDPK1 (0.83) | PDPK1PIK3CDPIK3CA | |
| SCHEMBL2426810 | 0.78 | PDPK1 (0.82) | PDPK1PIK3CDPIK3CAPAK1PAK4 | |
| SCHEMBL15562497 | 0.78 | PAK1 (0.68) | PDPK1PIK3CDPIK3CAPAK1PAK4 | |
| SCHEMBL19860022 | 0.77 | SIK1 (0.79) | PDPK1PIK3CDPIK3CAPAK1PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2291375-B1 | PYRROLOPYRIDINYLPYRIMIDIN-2-YLAMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-01-06 | — | — | EP | disclosed |