Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 17/20 | 0.90 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.78 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.78 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.59 |
| ▸ | PAK4 | O96013 | 1/20 | 0.52 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.52 |
| ▸ | SIK1 | P57059 | 1/20 | 0.50 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.50 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1457104 | 0.95 | PDPK1 (1.00) | PDPK1PIK3CAPIK3CDPIK3CGPAK4 | |
| SCHEMBL1456620 | 0.88 | PDPK1 (1.00) | PDPK1PIK3CAPIK3CDPIK3CGPAK4 | |
| SCHEMBL1456037 | 0.87 | PDPK1 (0.83) | PDPK1PIK3CAPIK3CDPIK3CG | |
| SCHEMBL12326157 | 0.85 | PDPK1 (0.71) | PDPK1PIK3CAPIK3CDPIK3CG | |
| SCHEMBL2423125 | 0.85 | PDPK1 (0.81) | PDPK1PIK3CAPIK3CDPIK3CGPAK4 | |
| SCHEMBL1456803 | 0.84 | PDPK1 (0.80) | PDPK1PIK3CAPIK3CDPAK4PAK1 | |
| SCHEMBL1456942 | 0.84 | PDPK1 (0.77) | PDPK1PIK3CAPIK3CDPIK3CGMET | |
| SCHEMBL1456008 | 0.84 | PDPK1 (0.77) | PDPK1PIK3CAPIK3CDPIK3CGPAK1 | |
| SCHEMBL17387699 | 0.84 | PDPK1 (0.79) | PDPK1PIK3CAPIK3CDPAK4PAK1 | |
| SCHEMBL27941411 | 0.83 | PDPK1 (0.76) | PDPK1PIK3CAPIK3CDPIK3CGPAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2291375-B1 | PYRROLOPYRIDINYLPYRIMIDIN-2-YLAMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-01-06 | — | — | EP | claimed |
| US-8420820-B2 | Pyrrolopyridinylpyrimidin-2-ylamine derivatives | MERCK PATENT GMBH (DE) | 2013-04-16 | — | — | US | claimed |
| US-20110218198-A1 | Pyrrolopyridinylpyrimidin-2-ylamine derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2011-09-08 | — | — | US | claimed |
| EP-2291375-B1 | PYRROLOPYRIDINYLPYRIMIDIN-2-YLAMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-01-06 | — | — | EP | disclosed |
| US-8420820-B2 | Pyrrolopyridinylpyrimidin-2-ylamine derivatives | MERCK PATENT GMBH (DE) | 2013-04-16 | — | — | US | disclosed |
| US-20110218198-A1 | Pyrrolopyridinylpyrimidin-2-ylamine derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2011-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110218198-A1 | Pyrrolopyridinylpyrimidin-2-ylamine derivatives | MKI67, CCNT1, CCNI | PDPK1 429/4885PIK3CA 2075/4885PIK3CD 3165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.