Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 3/20 | 0.35 |
| ▸ | HTR1D | P28221 | 3/20 | 0.35 |
| ▸ | HTR1B | P28222 | 3/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL620796 | 0.90 | KCNH2 (0.44) | KCNH2KCNQ1CACNA1C | |
| SCHEMBL622654 | 0.85 | MAOB (0.37) | MAOAMAOBDRD2HTR1AHTR1D | |
| SCHEMBL622311 | 0.84 | GSK3B (0.42) | GSK3B | |
| SCHEMBL620405 | 0.83 | HPGD (0.47) | KCNH2 | |
| SCHEMBL619401 | 0.81 | KCNH2 (0.38) | MAOAMAOBKCNH2KCNQ1CACNA1C | |
| SCHEMBL619623 | 0.79 | KCNH2 (0.50) | CXCR4SLC6A4HTR1AKCNH2 | |
| SCHEMBL620130 | 0.79 | HPGDS (0.39) | KCNH2 | |
| SCHEMBL622117 | 0.79 | HPGD (0.48) | — | |
| SCHEMBL622330 | 0.78 | KCNH2 (0.43) | KCNH2KCNQ1CACNA1C | |
| SCHEMBL621992 | 0.78 | KMT2A (0.42) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389376-A1 | NOVEL BICYCLIC ANTIBIOTICS | Basilea Pharmaceutica AG (CH) | 2011-11-30 | — | — | EP | disclosed |
| WO-2010084152-A1 | NOVEL BICYCLIC ANTIBIOTICS | BASILEA PHARMACEUTICA AG (CH) | 2010-07-29 | — | — | WO | disclosed |