Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Mephenytoin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 3/20 | 0.74 |
| ▸ | TSHR | P16473 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mephenytoin SCHEMBL21766 | 0.86 | CYP2C19 (1.00) | CYP2C19TSHRLMNAFPR2GAA | |
| Mephenytoin SCHEMBL21768 | 0.86 | CYP2C19 (1.00) | CYP2C19TSHRLMNAFPR2GAA | |
| Mephenytoin SCHEMBL4778454 | 0.82 | CYP2C19 (0.91) | CYP2C19TSHRLMNAFPR2GAA | |
| Phenytoin SCHEMBL9834729 | 0.78 | CYP2C19 (0.76) | CYP2C19TSHRLMNAFPR2GAA | |
| Phenobarbital SCHEMBL6426618 | 0.78 | CYP2C19 (0.76) | CYP2C19TSHRLMNAFPR2TDP1 | |
| Methsuximide SCHEMBL28248761 | 0.72 | CYP19A1 (0.55) | CYP2C19TSHRLMNAGAAMEN1 | |
| SCHEMBL5303102 | 0.72 | CYP2C19 (0.71) | CYP2C19TSHRLMNAFPR2GAA | |
| SCHEMBL14067600 | 0.72 | CYP2C19 (0.71) | CYP2C19TSHRLMNAFPR2GAA | |
| SCHEMBL28008015 | 0.72 | CYP2C19 (0.71) | CYP2C19TSHRLMNAFPR2GAA | |
| Hydantoin SCHEMBL27574136 | 0.68 | CRBN (0.46) | TDP1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016004396-A1 | TECHNOLOGIES FOR BRAIN EXERCISE TRAINING | DECHARMS CHRISTOPHER (US) | 2016-01-07 | — | — | WO | disclosed |