Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Mephenytoin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 3/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | FPR2 | P25090 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mephenytoin SCHEMBL21766 | 1.00 | CYP2C19 (1.00) | CYP2C19TSHRLMNAFPR2TDP1 | |
| Mephenytoin SCHEMBL4778454 | 0.95 | CYP2C19 (0.91) | CYP2C19TSHRLMNAFPR2TDP1 | |
| Phenobarbital SCHEMBL6426618 | 0.87 | CYP2C19 (0.76) | CYP2C19TSHRLMNAFPR2TDP1 | |
| Phenytoin SCHEMBL9834729 | 0.87 | CYP2C19 (0.76) | CYP2C19TSHRLMNAFPR2GAA | |
| Mephenytoin SCHEMBL17396223 | 0.86 | CYP2C19 (0.74) | CYP2C19TSHRLMNAFPR2TDP1 | |
| SCHEMBL28008015 | 0.83 | CYP2C19 (0.71) | CYP2C19TSHRLMNAFPR2GAA | |
| SCHEMBL14067600 | 0.83 | CYP2C19 (0.71) | CYP2C19TSHRLMNAFPR2GAA | |
| SCHEMBL5303102 | 0.83 | CYP2C19 (0.71) | CYP2C19TSHRLMNAFPR2TDP1 | |
| SCHEMBL28794825 | 0.78 | CYP2C19 (1.00) | CYP2C19TSHRLMNATDP1GAA | |
| SCHEMBL29549519 | 0.78 | CYP2C19 (1.00) | CYP2C19TSHRLMNATDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1393 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114590005-B | Antibacterial, antiviral and waterproof preparation and application thereof in preparation of protective clothing fabric | 绍兴崇高新材料科技有限公司 | 2024-08-30 | — | — | CN | claimed |
| EP-4232004-A1 | FRACTAL FORMULATIONS | Nanogyre Sprl (BE) | 2023-08-30 | — | — | EP | claimed |
| WO-2022164850-A1 | COMPOUNDS TO PREVENT OR TREAT SARS-CoV-2 VARIANT INFECTION | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2022-08-04 | — | — | WO | claimed |
| CN-114590005-A | Antibacterial and antiviral waterproof preparation and application thereof in preparation of protective clothing fabric | 绍兴崇高新材料科技有限公司 | 2022-06-07 | — | — | CN | claimed |
| CN-113248745-A | Acid coagulation preparation method of medical gloves | 南京润京乳胶制品有限公司 | 2021-08-13 | — | — | CN | claimed |
| WO-2021078412-A1 | FRACTAL FORMULATIONS | MESSADEK JALLAL (BE) | 2021-04-29 | — | — | WO | claimed |
| US-20200147076-A1 | PARENTERAL FORMULATIONS OF LIPOPHILIC PHARMACEUTICAL AGENTS AND METHODS FOR PREPARING AND USING THE SAME | PLATFORM BRIGHTWORKS TWO, LTD. (US) | 2020-05-14 | — | — | US | claimed |
| CN-109620977-A | A kind of medical conducting resinl and its preparation process and application | 索思（苏州）医疗科技有限公司 | 2019-04-16 | — | — | CN | claimed |
| CN-109457238-A | Stable chemical bronze plating liquid and preparation method thereof at a high speed | 上海昕沐化学科技有限公司 | 2019-03-12 | — | — | CN | claimed |
| US-20190000862-A1 | METHODS AND SYSTEMS FOR THE DELIVERY OF A THERAPEUTIC AGENT | HANANJA EHF (IS) | 2019-01-03 | — | — | US | claimed |
| US-20100140185-A1 | Wastewater treatment | HILL JOHN | 2010-06-10 | — | — | US | claimed |
| WO-2009040818-A9 | COMPOSITIONS COMPRISING LIPOPHILIC ACTIVE COMPOUNDS AND METHOD FOR THEIR PREPARATION | SOLUBEST LTD (IL) | 2010-05-20 | — | — | WO | claimed |
| US-20090098200-A1 | COMPOSITIONS COMPRISING LIPOPHILIC ACTIVE COMPOUNDS AND METHOD FOR THEIR PREPARATION | SOLUBEST LTD. (IL) | 2009-04-16 | — | — | US | claimed |
| WO-2009040818-A1 | COMPOSITIONS COMPRISING LIPOPHILIC ACTIVE COMPOUNDS AND METHOD FOR THEIR PREPARATION | SOLUBEST LTD (IL) | 2009-04-02 | — | — | WO | claimed |
| EP-1599098-A1 | PROCESS TO SANITIZE FRUIT AND VEGETABLES | Wobelea Pty. Limited (AU) | 2005-11-30 | — | — | EP | claimed |
| WO-2004073408-A1 | PROCESS TO SANITIZE FRUIT AND VEGETABLES | WOBELEA PTY. LIMITED (AU) | 2004-09-02 | — | — | WO | claimed |
| CN-1379686-A | Composition comprising tramadol material and anticonvulsant drug | ORTHO MCNEIL PHARM INC (US) | 2002-11-13 | — | — | CN | claimed |
| US-6210556-B1 | FOR DEPOSITING TIN-RICH TIN-SILVER ALLOYS UPON A SUBSTRATE | LEARONAL, INC. | 2001-04-03 | — | — | US | claimed |
| CN-1129942-A | Aza spiro-compounds acting on the cholinergic system with muscarinic agonist activity | ISRAEL INST BIOLOG RES (IL) | 1996-08-28 | — | — | CN | claimed |
| US-4657285-A | Tubular rubber products | BRIDGESTONE CORPORATION (JP) | 1987-04-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190000862-A1 | METHODS AND SYSTEMS FOR THE DELIVERY OF A THERAPEUTIC AGENT | TMEM205, NUP205, PIGS | CYP2C19 3652/4885TSHR 2469/4885LMNA 458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.