Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 5/20 | 0.58 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.55 |
| ▸ | DCLK1 | O15075 | 3/20 | 0.55 |
| ▸ | MAPK7 | Q13164 | 3/20 | 0.55 |
| ▸ | INSR | P06213 | 4/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.54 |
| ▸ | PLK1 | P53350 | 2/20 | 0.53 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 3/20 | 0.51 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17396462 | 0.91 | TTK (0.65) | TTKLRRK2DCLK1MAPK7INSR | |
| SCHEMBL17396401 | 0.87 | TTK (0.59) | TTKLRRK2DCLK1MAPK7INSR | |
| SCHEMBL17396399 | 0.86 | TTK (0.56) | TTKLRRK2DCLK1MAPK7INSR | |
| SCHEMBL17396530 | 0.86 | CDK4 (0.55) | — | |
| SCHEMBL17396590 | 0.83 | EGFR (0.57) | TTKLRRK2DCLK1MAPK7INSR | |
| SCHEMBL17396415 | 0.82 | TTK (0.56) | TTKLRRK2DCLK1MAPK7INSR | |
| SCHEMBL24496118 | 0.80 | MAPK7 (0.68) | LRRK2DCLK1MAPK7TNK2EGFR | |
| SCHEMBL27196830 | 0.79 | MAPK7 (0.59) | LRRK2DCLK1MAPK7TNK2EGFR | |
| SCHEMBL17396455 | 0.79 | CDK4 (0.61) | INSRALKEGFR | |
| SCHEMBL17396591 | 0.78 | LRRK2 (0.58) | TTKLRRK2DCLK1MAPK7INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001077-A1 | COMPOUNDS INHIBITING THE ENZYME MONOPOLAR SPINDLE 1 KINASE,PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2016-01-07 | — | — | WO | disclosed |