Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 10/20 | 0.61 |
| ▸ | CCND1 | P24385 | 9/20 | 0.61 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.61 |
| ▸ | CDK9 | P50750 | 3/20 | 0.61 |
| ▸ | RPS6KA6 | Q9UK32 | 2/20 | 0.57 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.57 |
| ▸ | CDK2 | P24941 | 4/20 | 0.57 |
| ▸ | CCND2 | P30279 | 4/20 | 0.57 |
| ▸ | CCND3 | P30281 | 4/20 | 0.57 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.57 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.57 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.57 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.57 |
| ▸ | PAK4 | O96013 | 1/20 | 0.57 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.57 |
| ▸ | CDK1 | P06493 | 3/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.56 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17396530 | 0.91 | CDK4 (0.55) | CDK4CCND1CCNT1CDK9RPS6KA6 | |
| SCHEMBL3971047 | 0.86 | RPS6KA6 (0.64) | CDK4CCND1CCNT1CDK9RPS6KA6 | |
| SCHEMBL13616064 | 0.83 | CDK4 (0.61) | CDK4CCND1CCNT1CDK9RPS6KA6 | |
| SCHEMBL3970477 | 0.80 | TNK2 (0.58) | CDK4CCND1CCNT1CDK9RPS6KA6 | |
| SCHEMBL30346164 | 0.80 | TNK2 (0.58) | CDK4CCND1CCNT1CDK9RPS6KA6 | |
| SCHEMBL17396393 | 0.79 | TTK (0.58) | INSREGFRALK | |
| SCHEMBL17396469 | 0.79 | STAT6 (0.58) | CDK4CCND1CCNT1CDK9CDK2 | |
| SCHEMBL17396422 | 0.78 | JAK3 (0.53) | CDK4CCND1CCNT1CDK9CCNE1 | |
| SCHEMBL3972872 | 0.78 | CDK4 (0.56) | CDK4CCND1CCNT1CDK9RPS6KA6 | |
| SCHEMBL7715488 | 0.78 | RPS6KA6 (0.64) | CDK4CCND1CCNT1CDK9RPS6KA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001077-A1 | COMPOUNDS INHIBITING THE ENZYME MONOPOLAR SPINDLE 1 KINASE,PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2016-01-07 | — | — | WO | claimed |
| WO-2016001077-A1 | COMPOUNDS INHIBITING THE ENZYME MONOPOLAR SPINDLE 1 KINASE,PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2016-01-07 | — | — | WO | disclosed |