Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | GHSR | Q92847 | 5/20 | 0.38 |
| ▸ | F2 | P00734 | 4/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 2/20 | 0.35 |
| ▸ | CTSD | P07339 | 2/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGAV | P06756 | 1/20 | 0.35 |
| ▸ | TACR2 | P21452 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17396412 | 0.81 | GSK3B (0.53) | TACR2 | |
| SCHEMBL17396441 | 0.80 | NOS1 (0.35) | — | |
| SCHEMBL17396400 | 0.74 | STAT6 (0.54) | — | |
| SCHEMBL1673516 | 0.72 | HDAC8 (0.57) | HDAC8GHSRHRH3CTSDITGB3 | |
| SCHEMBL1598687 | 0.72 | HDAC8 (0.57) | HDAC8GHSRHRH3CTSDITGB3 | |
| SCHEMBL7304234 | 0.72 | HDAC8 (0.57) | HDAC8GHSRHRH3CTSDITGB3 | |
| SCHEMBL8135311 | 0.69 | HDAC8 (0.54) | HDAC8GHSRHRH3CTSDITGB3 | |
| SCHEMBL12148795 | 0.69 | HDAC8 (0.54) | HDAC8GHSRHRH3CTSDITGB3 | |
| SCHEMBL10283637 | 0.67 | HDAC8 (0.56) | HDAC8HRH3 | |
| SCHEMBL1226583 | 0.67 | HDAC8 (0.56) | HDAC8HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001077-A1 | COMPOUNDS INHIBITING THE ENZYME MONOPOLAR SPINDLE 1 KINASE,PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2016-01-07 | — | — | WO | disclosed |