Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.50 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.50 |
| ▸ | MAPK7 | Q13164 | 2/20 | 0.50 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.47 |
| ▸ | INSR | P06213 | 3/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.46 |
| ▸ | TTK | P33981 | 2/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.43 |
| ▸ | DCLK2 | Q8N568 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17396471 | 0.90 | EGFR (0.54) | EGFRLRRK2DCLK1MAPK7TNK2 | |
| SCHEMBL17396417 | 0.82 | DCLK1 (0.52) | EGFRLRRK2DCLK1MAPK7TNK2 | |
| SCHEMBL17396467 | 0.81 | LRRK2 (0.54) | EGFRLRRK2DCLK1MAPK7TNK2 | |
| SCHEMBL17396590 | 0.76 | EGFR (0.57) | EGFRLRRK2DCLK1MAPK7TNK2 | |
| SCHEMBL17396591 | 0.76 | LRRK2 (0.58) | EGFRLRRK2DCLK1MAPK7TNK2 | |
| SCHEMBL17396401 | 0.76 | TTK (0.59) | EGFRLRRK2DCLK1MAPK7TNK2 | |
| SCHEMBL17396567 | 0.74 | TTK (0.54) | EGFRLRRK2DCLK1MAPK7TNK2 | |
| SCHEMBL17396576 | 0.74 | DCLK1 (0.53) | EGFRLRRK2DCLK1MAPK7TNK2 | |
| SCHEMBL17396415 | 0.71 | TTK (0.56) | EGFRLRRK2DCLK1MAPK7ALK | |
| SCHEMBL17396371 | 0.71 | TTK (0.61) | EGFRLRRK2DCLK1MAPK7TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001077-A1 | COMPOUNDS INHIBITING THE ENZYME MONOPOLAR SPINDLE 1 KINASE,PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2016-01-07 | — | — | WO | claimed |
| WO-2016001077-A1 | COMPOUNDS INHIBITING THE ENZYME MONOPOLAR SPINDLE 1 KINASE,PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2016-01-07 | — | — | WO | disclosed |