Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 2/20 | 0.54 |
| ▸ | PLK1 | P53350 | 2/20 | 0.54 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.54 |
| ▸ | MAPK7 | Q13164 | 2/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 15/20 | 0.53 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.52 |
| ▸ | PLK4 | O00444 | 2/20 | 0.49 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.49 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | PI4KA | P42356 | 1/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.48 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.48 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.48 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.48 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.48 |
| ▸ | DCLK2 | Q8N568 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17396576 | 0.87 | DCLK1 (0.53) | TTKPLK1DCLK1MAPK7LRRK2 | |
| SCHEMBL17396417 | 0.84 | DCLK1 (0.52) | TTKPLK1DCLK1MAPK7LRRK2 | |
| SCHEMBL17396404 | 0.81 | TTK (0.70) | TTKPLK1DCLK1MAPK7LRRK2 | |
| SCHEMBL17396437 | 0.81 | LRRK2 (0.57) | TTKPLK1DCLK1MAPK7LRRK2 | |
| SCHEMBL17396494 | 0.80 | TTK (0.59) | TTKPLK1DCLK1MAPK7LRRK2 | |
| SCHEMBL17396371 | 0.79 | TTK (0.61) | TTKPLK1DCLK1MAPK7LRRK2 | |
| SCHEMBL17396467 | 0.78 | LRRK2 (0.54) | DCLK1MAPK7LRRK2EGFRTNK2 | |
| SCHEMBL17396471 | 0.76 | EGFR (0.54) | TTKPLK1DCLK1MAPK7LRRK2 | |
| SCHEMBL17396589 | 0.74 | TTK (0.65) | TTKPLK1DCLK1MAPK7LRRK2 | |
| SCHEMBL17396452 | 0.74 | EGFR (0.52) | TTKDCLK1MAPK7LRRK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001077-A1 | COMPOUNDS INHIBITING THE ENZYME MONOPOLAR SPINDLE 1 KINASE,PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2016-01-07 | — | — | WO | claimed |
| WO-2016001077-A1 | COMPOUNDS INHIBITING THE ENZYME MONOPOLAR SPINDLE 1 KINASE,PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2016-01-07 | — | — | WO | disclosed |