Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 9/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17397290 | 0.83 | PIK3CD (0.53) | PIK3CDPIK3CBPIK3CALMNAPOLB | |
| SCHEMBL17397167 | 0.83 | PIK3CD (0.46) | PIK3CDPIK3CBPIK3CALMNAPOLB | |
| SCHEMBL17397245 | 0.80 | PIK3CD (0.49) | PIK3CDPIK3CBPIK3CALMNAPOLB | |
| SCHEMBL17397151 | 0.79 | PIK3CD (0.54) | PIK3CDPIK3CBPIK3CA | |
| SCHEMBL17397225 | 0.79 | PIK3CD (0.66) | PIK3CDPIK3CBPIK3CA | |
| SCHEMBL17401154 | 0.79 | PIK3CD (0.66) | PIK3CDPIK3CBPIK3CA | |
| SCHEMBL17397286 | 0.79 | PIK3CD (0.50) | PIK3CDPIK3CBPIK3CALMNAPOLB | |
| SCHEMBL17397231 | 0.78 | PIK3CD (0.47) | PIK3CDPIK3CBPIK3CALMNAPOLB | |
| SCHEMBL17397143 | 0.76 | PIK3CD (0.46) | PIK3CDPIK3CBPIK3CALMNAPOLB | |
| SCHEMBL17397252 | 0.76 | PIK3CD (0.44) | PIK3CDPIK3CBPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3164400-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | Lupin Limited (IN) | 2017-05-10 | — | — | EP | claimed |
| WO-2016001855-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | LUPIN LIMITED (IN) | 2016-01-07 | — | — | WO | claimed |
| EP-3164400-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | Lupin Limited (IN) | 2017-05-10 | — | — | EP | disclosed |
| WO-2016001855-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | LUPIN LIMITED (IN) | 2016-01-07 | — | — | WO | disclosed |