Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 4/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | STK3 | Q13188 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | ROS1 | P08922 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17397143 | 0.90 | PIK3CD (0.46) | PIK3CDPIK3CBAURKACDK1STK3 | |
| SCHEMBL17397290 | 0.86 | PIK3CD (0.53) | PIK3CDPIK3CBAURKACDK1PDPK1 | |
| SCHEMBL17397151 | 0.82 | PIK3CD (0.54) | PIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL17397286 | 0.81 | PIK3CD (0.50) | PIK3CDPIK3CBAURKACDK1STK3 | |
| SCHEMBL17397167 | 0.81 | PIK3CD (0.46) | PIK3CDPIK3CBAURKAMAP4K4DYRK1A | |
| SCHEMBL17397231 | 0.80 | PIK3CD (0.47) | PIK3CDPIK3CBLMNAPOLBPIK3CA | |
| SCHEMBL17397226 | 0.80 | PIK3CD (0.45) | PIK3CDPIK3CBAURKAFGFR1LMNA | |
| SCHEMBL17401173 | 0.79 | PIK3CD (0.72) | PIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL17397244 | 0.79 | PIK3CD (0.72) | PIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL17397071 | 0.79 | PIK3CD (0.46) | PIK3CDPIK3CBPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3164400-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | Lupin Limited (IN) | 2017-05-10 | — | — | EP | claimed |
| WO-2016001855-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | LUPIN LIMITED (IN) | 2016-01-07 | — | — | WO | claimed |
| EP-3164400-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | Lupin Limited (IN) | 2017-05-10 | — | — | EP | disclosed |
| WO-2016001855-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | LUPIN LIMITED (IN) | 2016-01-07 | — | — | WO | disclosed |