Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CHKA | P35790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30899506 | 0.95 | ALDH1A1 (0.37) | ALDH1A1F2ATMHPGDMEN1 | |
| SCHEMBL11055867 | 0.90 | POLB (0.35) | ALDH1A1HPGDMEN1KMT2ATDP1 | |
| SCHEMBL11303163 | 0.86 | ALDH1A1 (0.34) | ALDH1A1F2MEN1KMT2A | |
| SCHEMBL11052035 | 0.81 | ALDH1A1 (0.32) | ALDH1A1TDP1 | |
| SCHEMBL17394891 | 0.74 | ATM (0.31) | ALDH1A1ATML3MBTL1MEN1KMT2A | |
| SCHEMBL1302798 | 0.74 | ALDH1A1 (0.46) | ALDH1A1F2ATMHPGDL3MBTL1 | |
| SCHEMBL27419530 | 0.73 | SMN1; SMN2 (0.36) | ALDH1A1F2HPGDL3MBTL1KMT2A | |
| SCHEMBL8288869 | 0.73 | ALDH1A1 (0.56) | ALDH1A1ATMHPGDMMP1MMP2 | |
| SCHEMBL4153578 | 0.72 | ALDH1A1 (0.50) | ALDH1A1F2ATMHPGDL3MBTL1 | |
| SCHEMBL5960405 | 0.72 | ALDH1A1 (0.50) | ALDH1A1F2ATMHPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016004272-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2016-01-07 | — | — | WO | claimed |
| WO-2016004272-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2016-01-07 | — | — | WO | disclosed |