Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 4/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.44 |
| ▸ | CDK9 | P50750 | 3/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162470 | 0.81 | NUDT1 (0.44) | CDK5CDK5R1CCNT1CDK9NUDT1 | |
| SCHEMBL28128988 | 0.79 | TSHR (0.35) | CDK5CDK5R1CCNT1CDK9 | |
| SCHEMBL12336950 | 0.79 | TLR8 (0.47) | CDK5CDK5R1CCNT1CDK9NUDT1 | |
| SCHEMBL31298388 | 0.78 | HRH4 (0.42) | CDK5CDK5R1CCNT1CDK9NUDT1 | |
| SCHEMBL25942317 | 0.78 | SMN1; SMN2 (0.38) | CDK5CDK5R1CCNT1CDK9 | |
| SCHEMBL9324642 | 0.77 | POLB (0.45) | DYRK1AAURKAHSP90AA1PRKACAADORA2A | |
| SCHEMBL12514073 | 0.76 | TLR8 (0.53) | NUDT1HRH4HRH3TLR8 | |
| SCHEMBL12439674 | 0.76 | NUDT1 (0.51) | NUDT1HRH4HRH3TLR8AURKA | |
| SCHEMBL1016115 | 0.75 | KCNH2 (0.54) | — | |
| SCHEMBL8127847 | 0.75 | HRH4 (0.42) | NUDT1HRH4HRH3TLR8AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1109055-A | 4-aminopyrimidine derivatives | ONO PHARMACEUTICAL CO (JP) | 1995-09-27 | — | — | CN | claimed |
| WO-2016000615-A1 | HETEROARYL COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2016-01-07 | — | — | WO | disclosed |
| CN-1109055-A | 4-aminopyrimidine derivatives | ONO PHARMACEUTICAL CO (JP) | 1995-09-27 | — | — | CN | disclosed |