Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 7/20 | 0.43 |
| ▸ | ALPL | P05186 | 2/20 | 0.42 |
| ▸ | ALPI | P09923 | 1/20 | 0.42 |
| ▸ | ALPG | P10696 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GRM5 | P41594 | 8/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1739234 | 0.92 | S1PR1 (0.50) | S1PR1S1PR3 | |
| SCHEMBL1740593 | 0.92 | S1PR1 (0.43) | S1PR1MEN1KMT2AS1PR3 | |
| SCHEMBL1739217 | 0.91 | S1PR1 (0.43) | S1PR1ALPLALPIKMT2AS1PR3 | |
| SCHEMBL1740702 | 0.88 | S1PR1 (0.43) | S1PR1S1PR3 | |
| SCHEMBL1738095 | 0.88 | S1PR1 (0.49) | S1PR1S1PR3 | |
| SCHEMBL1739403 | 0.87 | S1PR1 (0.44) | S1PR1S1PR3 | |
| SCHEMBL1739204 | 0.87 | S1PR1 (0.44) | S1PR1S1PR3 | |
| SCHEMBL1740563 | 0.86 | LMNA (0.42) | S1PR1MEN1KMT2A | |
| SCHEMBL1738093 | 0.85 | S1PR1 (0.42) | S1PR1S1PR3 | |
| SCHEMBL1738358 | 0.85 | S1PR1 (0.41) | S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2390252-A1 | New pyrazole derivatives | Almirall, S.A. (ES) | 2011-11-30 | — | — | EP | claimed |
| WO-2011144338-A1 | PYRAZOLE DERIVATIVES AS S1P1 AGONISTS | ALMIRALL, S.A. (ES) | 2011-11-24 | — | — | WO | claimed |
| EP-2390252-A1 | New pyrazole derivatives | Almirall, S.A. (ES) | 2011-11-30 | — | — | EP | disclosed |
| WO-2011144338-A1 | PYRAZOLE DERIVATIVES AS S1P1 AGONISTS | ALMIRALL, S.A. (ES) | 2011-11-24 | — | — | WO | disclosed |