Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | STAT1 | P42224 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 7/20 | 0.43 |
| ▸ | CDK1 | P06493 | 4/20 | 0.43 |
| ▸ | FLT3 | P36888 | 3/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17398085 | 0.92 | CDK2 (0.53) | MAPTALDH1A1KDM4ELMNAGAA | |
| SCHEMBL17397972 | 0.90 | TNIK (0.48) | MAPTNPC1RAB9ATNIKCDK2 | |
| SCHEMBL17413483 | 0.90 | CHEK1 (0.42) | MAPTALDH1A1KDM4ELMNAGAA | |
| SCHEMBL17398041 | 0.90 | TNIK (0.45) | MAPTALDH1A1KDM4ELMNAGAA | |
| SCHEMBL17397946 | 0.89 | CDK2 (0.57) | MAPTCDK2CDK1FLT3AURKA | |
| SCHEMBL17398048 | 0.88 | CDK2 (0.41) | CDK2CDK1FLT3AURKAFLT1 | |
| SCHEMBL17398076 | 0.87 | CDK2 (0.40) | TNIKCDK2CDK1 | |
| SCHEMBL17398070 | 0.85 | TNIK (0.44) | MAPTALDH1A1KDM4ELMNAGAA | |
| SCHEMBL17398058 | 0.84 | AURKA (0.49) | FLT3AURKAFLT1KDRPAK4 | |
| SCHEMBL17397903 | 0.84 | PAK4 (0.42) | MAPTALDH1A1KDM4ELMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |