Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 14/20 | 0.49 |
| ▸ | GSK3B | P49841 | 9/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.49 |
| ▸ | GSK3A | P49840 | 2/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | LTK | P29376 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17398016 | 0.84 | MAPT (0.45) | AURKAPAK4FLT1KDRFLT3 | |
| SCHEMBL17398008 | 0.84 | AURKA (0.41) | AURKAGSK3BAURKBGSK3ADAPK3 | |
| SCHEMBL17398043 | 0.83 | AURKA (0.44) | AURKAGSK3BAURKBGSK3AJAK2 | |
| SCHEMBL17397977 | 0.81 | JAK1 (0.39) | AURKAGSK3BAURKBGSK3ADAPK3 | |
| SCHEMBL17397940 | 0.81 | AURKA (0.43) | AURKAGSK3BAURKBGSK3ADAPK3 | |
| SCHEMBL17397951 | 0.81 | AURKA (0.43) | AURKAGSK3BAURKBGSK3ADAPK3 | |
| SCHEMBL17397974 | 0.81 | AURKA (0.48) | AURKAGSK3BAURKBGSK3ADAPK3 | |
| SCHEMBL17397972 | 0.80 | TNIK (0.48) | PRKAA1 | |
| SCHEMBL17398085 | 0.80 | CDK2 (0.53) | PDGFRBFLT3NTRK1 | |
| SCHEMBL17398084 | 0.80 | LCK (0.47) | AURKBLCKIGF1RITKPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |