Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 7/20 | 0.72 |
| ▸ | TNF | P01375 | 9/20 | 0.66 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.52 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL860004 | 0.89 | RIPK1 (0.74) | RIPK1TNFRIPK2KMT2AL3MBTL1 | |
| SCHEMBL20053036 | 0.89 | RIPK1 (0.74) | RIPK1TNFRIPK2KMT2AL3MBTL1 | |
| SCHEMBL17471693 | 0.87 | RIPK1 (0.71) | RIPK1TNFRIPK2RIPK3KMT2A | |
| SCHEMBL17830325 | 0.86 | TNF (0.66) | RIPK1TNFRIPK2RIPK3KMT2A | |
| SCHEMBL17471746 | 0.85 | RIPK1 (0.69) | RIPK1TNFRIPK2RIPK3KMT2A | |
| SCHEMBL17830343 | 0.85 | RIPK1 (0.62) | RIPK1TNFRIPK2RIPK3KMT2A | |
| SCHEMBL860317 | 0.84 | RIPK1 (1.00) | RIPK1TNFRIPK2RIPK3KMT2A | |
| SCHEMBL859956 | 0.84 | RIPK1 (1.00) | RIPK1TNFRIPK2RIPK3KMT2A | |
| SCHEMBL859928 | 0.84 | RIPK1 (1.00) | RIPK1TNFRIPK2RIPK3KMT2A | |
| SCHEMBL29638037 | 0.84 | RIPK1 (1.00) | RIPK1TNFRIPK2RIPK3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3081214-A2 | INHIBITORS OF CELLULAR NECROSIS | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2016-10-19 | — | — | EP | disclosed |
| EP-2384753-B1 | Hydantoin derivatives as inhibitors of cellular necrosis | BRIGHAM & WOMENS HOSPITAL (US) | 2016-01-06 | — | — | EP | disclosed |