Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 12/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.42 |
| ▸ | NEK2 | P51955 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18470604 | 0.98 | MPL (0.48) | MPLADORA3NEK2CHRM4PDCD1 | |
| SCHEMBL21301162 | 0.98 | MPL (0.48) | MPLADORA3NEK2CHRM4PDCD1 | |
| SCHEMBL17400652 | 0.93 | MPL (0.47) | MPLADORA3NEK2CHRM4PDCD1 | |
| SCHEMBL17400698 | 0.93 | MPL (0.57) | MPLADORA3 | |
| SCHEMBL17412810 | 0.92 | ADORA3 (0.43) | MPLADORA3NEK2PDCD1CD274 | |
| SCHEMBL18470816 | 0.92 | MPL (0.51) | MPLADORA3 | |
| SCHEMBL17400629 | 0.92 | MPL (0.49) | MPLADORA3 | |
| SCHEMBL17400668 | 0.92 | MPL (0.51) | MPLADORA3 | |
| SCHEMBL17400513 | 0.92 | MPL (0.51) | MPLADORA3 | |
| SCHEMBL17400641 | 0.91 | MPL (0.45) | MPLADORA3NEK2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9562044-B2 | 2-acylaminothiazole derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2017-02-07 | — | — | US | disclosed |
| EP-2963036-A1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF | Astellas Pharma Inc. (JP) | 2016-01-06 | — | — | EP | disclosed |