Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 7/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 3/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17400500 | 0.94 | MPL (0.41) | MPLTRPV4BRAFPDCD1CD274 | |
| SCHEMBL17400616 | 0.94 | MPL (0.41) | MPLTRPV4BRAFPDCD1CD274 | |
| SCHEMBL17412730 | 0.92 | TRPV4 (0.35) | MPLTRPV4PDCD1CD274ADORA3 | |
| SCHEMBL17400674 | 0.91 | MPL (0.51) | MPLADORA3S1PR1 | |
| SCHEMBL17386604 | 0.91 | MPL (0.51) | MPLADORA3S1PR1 | |
| SCHEMBL17400637 | 0.91 | MPL (0.51) | MPLADORA3S1PR1 | |
| Hydrochloric Acid SCHEMBL30938547 | 0.90 | MPL (0.50) | MPLADORA3S1PR1 | |
| SCHEMBL21007333 | 0.90 | MPL (0.41) | MPLTRPV4BRAFPDCD1CD274 | |
| SCHEMBL18724465 | 0.90 | MPL (0.41) | MPLTRPV4BRAFPDCD1CD274 | |
| SCHEMBL17400681 | 0.89 | MPL (0.50) | MPLADORA3S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9562044-B2 | 2-acylaminothiazole derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2017-02-07 | — | — | US | disclosed |
| EP-2963036-A1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF | Astellas Pharma Inc. (JP) | 2016-01-06 | — | — | EP | disclosed |