⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2738581 | 0.78 | — | — | |
| SCHEMBL17428634 | 0.73 | — | — | |
| SCHEMBL25792658 | 0.73 | — | — | |
| SCHEMBL18730157 | 0.68 | — | — | |
| SCHEMBL25792748 | 0.67 | KDM4E (0.39) | — | |
| SCHEMBL20048887 | 0.67 | — | — | |
| SCHEMBL14533807 | 0.67 | — | — | |
| SCHEMBL2738585 | 0.67 | — | — | |
| SCHEMBL13942620 | 0.67 | — | — | |
| SCHEMBL17793414 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3050882-A1 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | Incyte Holdings Corporation (US) | 2016-08-03 | — | — | EP | disclosed |
| EP-2545045-B1 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | INCYTE HOLDINGS CORP (US) | 2016-01-06 | — | — | EP | disclosed |