Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21721621 | 0.82 | LMNA (0.38) | HTR2AACHE | |
| SCHEMBL15849397 | 0.78 | PDE4B (0.35) | PDE4BPDE3AHTR2AHTR2CACHE | |
| SCHEMBL19296842 | 0.73 | PDE4B (0.33) | PDE4BPDE3AHTR2AHTR2C | |
| SCHEMBL21721622 | 0.72 | CNR2 (0.46) | — | |
| SCHEMBL4061102 | 0.71 | PTPN1 (0.41) | — | |
| SCHEMBL20906118 | 0.69 | PDE4B (0.38) | PDE4BPDE3AACHE | |
| SCHEMBL4062812 | 0.69 | MAPT (0.42) | — | |
| SCHEMBL17400887 | 0.68 | DAO (0.32) | — | |
| SCHEMBL26281479 | 0.68 | — | — | |
| SCHEMBL27699266 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3050882-A1 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | Incyte Holdings Corporation (US) | 2016-08-03 | — | — | EP | disclosed |
| EP-2545045-B1 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | INCYTE HOLDINGS CORP (US) | 2016-01-06 | — | — | EP | disclosed |