Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.58 |
| ▸ | DHFR | P00374 | 8/20 | 0.56 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.54 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819746 | 1.00 | TSHR (0.66) | TSHRGGPS1DHFRPLA2G4BSMPD1 | |
| SCHEMBL15922807 | 1.00 | TSHR (0.66) | TSHRGGPS1DHFRPLA2G4BSMPD1 | |
| SCHEMBL25170047 | 1.00 | TSHR (0.66) | TSHRGGPS1DHFRPLA2G4BSMPD1 | |
| SCHEMBL15923537 | 1.00 | TSHR (0.66) | TSHRGGPS1DHFRPLA2G4BSMPD1 | |
| SCHEMBL6529839 | 0.98 | TSHR (0.63) | TSHRGGPS1DHFRPLA2G4B | |
| Hydrazine SCHEMBL15923135 | 0.97 | TSHR (0.62) | TSHRGGPS1DHFRPLA2G4BSMPD1 | |
| Hydrazine SCHEMBL15923078 | 0.97 | TSHR (0.62) | TSHRGGPS1DHFRPLA2G4BSMPD1 | |
| SCHEMBL24675796 | 0.94 | TSHR (0.59) | TSHRGGPS1DHFRPLA2G4BSMPD1 | |
| SCHEMBL2903758 | 0.93 | TSHR (0.56) | TSHRGGPS1DHFRPLA2G4B | |
| SCHEMBL12408537 | 0.91 | PRSS1 (0.51) | TSHRGGPS1DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9849099-B2 | Antimicrobial compounds, compositions and methods of use thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2017-12-26 | — | — | US | disclosed |
| US-9849099-B2 | Antimicrobial compounds, compositions and methods of use thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2017-12-26 | — | — | US | disclosed |
| US-20160374964-A1 | ANTIMICROBIAL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-12-29 | — | — | US | disclosed |
| US-9440920-B2 | Antimicrobial compounds, compositions and methods of use thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2016-09-13 | — | — | US | disclosed |
| US-9440920-B2 | Antimicrobial compounds, compositions and methods of use thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2016-09-13 | — | — | US | disclosed |
| US-20160002163-A1 | ANTIMICROBIAL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-01-07 | — | — | US | disclosed |
| US-20160002163-A1 | ANTIMICROBIAL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160002163-A1 | ANTIMICROBIAL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | PCNA, TOP1, SPOUT1 | TSHR 4290/4885GGPS1 1558/4885DHFR 904/4885 |
| US-20160374964-A1 | ANTIMICROBIAL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | PCNA, TOP1, SPOUT1 | TSHR 4290/4885GGPS1 1558/4885DHFR 904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.