Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.74 |
| ▸ | NPC1 | O15118 | 3/20 | 0.74 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.55 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 4/20 | 0.53 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.52 |
| ▸ | TUBB | P07437 | 3/20 | 0.52 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11716691 | 0.88 | NPC1 (0.65) | RAB9ANPC1MAPTMAPK1L3MBTL1 | |
| SCHEMBL162121 | 0.88 | NPC1 (0.56) | RAB9ANPC1MAPTMAPK1L3MBTL1 | |
| SCHEMBL161998 | 0.88 | NPC1 (0.56) | RAB9ANPC1MAPTMAPK1L3MBTL1 | |
| SCHEMBL24326606 | 0.86 | RAB9A (1.00) | RAB9ANPC1MAPTMAPK1L3MBTL1 | |
| SCHEMBL162122 | 0.84 | MAPT (0.54) | RAB9ANPC1MAPTMAPK1L3MBTL1 | |
| SCHEMBL20844841 | 0.82 | RAB9A (0.91) | RAB9ANPC1MAPTMAPK1L3MBTL1 | |
| SCHEMBL11713855 | 0.81 | MAPT (0.56) | RAB9ANPC1MAPTMAPK1L3MBTL1 | |
| SCHEMBL12188551 | 0.79 | NPC1 (0.85) | RAB9ANPC1MAPTMAPK1L3MBTL1 | |
| SCHEMBL14147290 | 0.78 | NPC1 (0.53) | RAB9ANPC1MAPTMAPK1L3MBTL1 | |
| SCHEMBL14147297 | 0.77 | NPC1 (0.51) | RAB9ANPC1MAPTMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |