Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1740687 | 0.81 | HPGDS (0.50) | HPGDSKDM4EIRAK4DYRK1APDGFRB | |
| SCHEMBL1741939 | 0.77 | HPGDS (0.48) | HPGDSKDM4EIRAK4DYRK1APDGFRB | |
| SCHEMBL2169923 | 0.73 | PDGFRB (0.42) | HPGDSKDM4EPDGFRBPDGFRACYP1A2 | |
| SCHEMBL15661914 | 0.72 | PDGFRB (0.39) | HPGDSKDM4EPDGFRBPDGFRACYP1A2 | |
| SCHEMBL622368 | 0.71 | FGFR3 (0.49) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL15662779 | 0.70 | FGFR3 (0.40) | KDM4EPDGFRBPDGFRALMNAFGFR1 | |
| Hydrochloric Acid SCHEMBL23360380 | 0.69 | PDGFRB (0.51) | HPGDSKDM4EIRAK4DYRK1APDGFRB | |
| Hydrochloric Acid SCHEMBL29862714 | 0.69 | HPGDS (0.62) | HPGDSIRAK4DYRK1APDGFRBPDGFRA | |
| Hydrochloric Acid SCHEMBL23360217 | 0.69 | HPGDS (0.62) | HPGDSIRAK4DYRK1APDGFRBPDGFRA | |
| SCHEMBL15661703 | 0.69 | FGFR3 (0.42) | PDGFRBPDGFRAFGFR1FGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389376-A1 | NOVEL BICYCLIC ANTIBIOTICS | Basilea Pharmaceutica AG (CH) | 2011-11-30 | — | — | EP | disclosed |
| WO-2010084152-A1 | NOVEL BICYCLIC ANTIBIOTICS | BASILEA PHARMACEUTICA AG (CH) | 2010-07-29 | — | — | WO | disclosed |