(+)-Ehna

(+)-Ehna

SCHEMBL1740490

CCCCCCC(C(C)O)n1cnc2c(N)ncnc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ADA P00813 6/20 1.00
PDE2A O00408 3/20 1.00
CYP3A4 P08684 2/20 1.00
PDE4A P27815 1/20 1.00
PDE4B Q07343 1/20 1.00
PDE4C Q08493 1/20 1.00
PDE4D Q08499 1/20 1.00
KDM4E B2RXH2 1/20 1.00
ALDH1A1 P00352 1/20 1.00
CYP1A2 P05177 1/20 1.00
ALOX15 P16050 1/20 1.00
SMN1; SMN2 Q16637 1/20 1.00
HSD17B10 Q99714 1/20 1.00
TSHR P16473 1/20 1.00
HIF1A Q16665 1/20 1.00
LMNA P02545 1/20 0.98
BLM P54132 1/20 0.98

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ehna SCHEMBL1742893 1.00 ADA (1.00) ADAPDE2ACYP3A4PDE4APDE4B
(+)-Ehna SCHEMBL1742728 1.00 ADA (1.00) ADAPDE2ACYP3A4PDE4APDE4B
(+)-Ehna SCHEMBL14985129 1.00 ADA (1.00) ADAPDE2ACYP3A4PDE4APDE4B
(+)-Ehna SCHEMBL29481903 0.99 PDE2A (1.00) ADAPDE2ACYP3A4PDE4APDE4B
(+)-Ehna SCHEMBL14975587 0.99 PDE2A (1.00) ADAPDE2ACYP3A4PDE4APDE4B
Ehna SCHEMBL29391683 0.99 PDE2A (1.00) ADAPDE2ACYP3A4PDE4APDE4B
SCHEMBL1740514 0.99 ADA (0.98) ADAPDE2ACYP3A4PDE4APDE4B
SCHEMBL9083113 0.90 ADA (0.82) ADAPDE2ACYP3A4PDE4APDE4B
SCHEMBL9083109 0.90 ADA (0.82) ADAPDE2ACYP3A4PDE4APDE4B
SCHEMBL8585722 0.90 ADA (0.82) ADAPDE2ACYP3A4PDE4APDE4B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 151 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3713572-B1 TREATMENT OF TACHYCARDIA OSLO UNIV HOSPITAL HF (NO) 2025-07-30 EP claimed
CN-120018870-A Drug coated medical device and method of manufacture 巴德血管外围设备公司 2025-05-16 CN claimed
US-12280057-B2 Vasoactive topical compound to affect tissue blood flow, reduce tissue necrosis and promote healing SOUTH DAKOTA BOARD OF REGENTS (US) 2025-04-22 US claimed
WO-2025075499-A1 REDUCING DOPAMINE FEED-BACK INHIBITION IN DOPAMINERGIC CELLS BY TADALAFIL. UNIVERSITEIT VAN AMSTERDAM (NL) 2025-04-10 WO claimed
WO-2024191445-A1 THERAPEUTIC BIO-ABSORBABLE POLYMERIC SCAFFOLD WITH DRUG-LOADED MICRO-NEEDLES FOR DRUG DELIVERY BECTON, DICKINSON AND COMPANY (US) 2024-09-19 WO claimed
WO-2024168242-A1 POINT-OF-CARE DEVICE FOR THE DETERMINATION OF ADENOSINE DEAMINASE ACTIVITY IN BIOLOGICAL SAMPLES IN VITRO DIAGNOSTIC SOLUTIONS (US) 2024-08-15 WO claimed
WO-2023012244-A1 COMBINATION THERAPY JAZ Innovation Limited (GB) 2023-02-09 WO claimed
US-20220362251-A1 TREATMENT OF TACHYCARDIA OSLO UNIVERSITY HOSPITAL HF (NO) 2022-11-17 US claimed
US-11419874-B2 Treatment of tachycardia OSLO UNIVERSITY HOSPITAL HF (NO) 2022-08-23 US claimed
CN-111239303-B Method for simultaneously determining concentrations of ticagrelor, active metabolites thereof and endogenous adenosine in human plasma by liquid chromatography-mass spectrometry 上海长海医院 2022-07-22 CN claimed
EP-3979996-A1 METHODS AND FORMULATIONS FOR TREATING VISION DISORDERS Jenivision Inc. (US) 2022-04-13 EP claimed
CN-113993511-A Methods and formulations for treating visual disorders 杰尼视界公司 2022-01-28 CN claimed
CN-104725628-B A kind of single functionalization branched polyethylene glycol, preparation method and its bio-related substance containing degradable group 厦门赛诺邦格生物科技股份有限公司 2018-04-17 CN claimed
US-20120202287-A1 Stem Cell Culture Methods ITI SCOTLAND LIMITED (GB) 2012-08-09 US claimed
EP-2389436-A2 STEM CELL CULTURE METHODS ITI Scotland Limited (GB) 2011-11-30 EP claimed
US-20110257911-A1 SYSTEMS AND METHODS FOR DETECTING CHANGES IN ENERGY USAGE IN A BUILDING JOHNSON CONTROLS TECHNOLOGY COMPANY 2011-10-20 US claimed
WO-2010084300-A2 STEM CELL CULTURE METHODS ITI SCOTLAND LIMITED (GB) 2010-07-29 WO claimed
US-7507707-B2 Methods of inducing ovulation using a non-polypeptide camp level modulator LABORATOIRES SERONO SA (CH) 2009-03-24 US claimed
EP-4676556-A1 RADIATION SPACER HYDROGELS, METHODS OF FORMING, AND METHODS OF USE Clearstream Technologies Limited (IE) 2026-01-14 EP disclosed
EP-0227844-A1 ANTIVIRAL DRUG TEIJIN LIMITED (JP) 1987-07-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11419874-B2 Treatment of tachycardia PDE4B, PDE2A, PDE5A ADA 2521/4885PDE2A 2/4885CYP3A4 566/4885
US-20220362251-A1 TREATMENT OF TACHYCARDIA PDE12, PDE2A, PDE4B ADA 2259/4885PDE2A 2/4885CYP3A4 570/4885
US-20120202287-A1 Stem Cell Culture Methods KIT, SOX18, MCL1 ADA 4438/4885PDE2A 3669/4885CYP3A4 4330/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.