Sugi Predict

Sugi Predict / Compounds / SCHEMBL17405153

SCHEMBL17405153

SCHEMBL17405153

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nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ STAT3 P40763 2/20 0.69
▸ PTAFR P25105 1/20 0.39
▸ CYP3A4 P08684 4/20 0.37
▸ ALDH1A1 P00352 4/20 0.35
▸ LMNA P02545 3/20 0.35
▸ TP53 P04637 3/20 0.35
▸ HIF1A Q16665 3/20 0.35
▸ NLRP3 Q96P20 2/20 0.35
▸ NFKB1 P19838 2/20 0.35
▸ CYP1A2 P05177 2/20 0.35
▸ STAT6 P42226 2/20 0.35
▸ MAPT P10636 2/20 0.35
▸ MAPK1 P28482 2/20 0.35
▸ PKM P14618 1/20 0.35
▸ CASP1 P29466 1/20 0.35
▸ PTGS2 P35354 1/20 0.35
▸ NFKB2 Q00653 1/20 0.35
▸ RELA Q04206 1/20 0.35
▸ CYP2D6 P10635 1/20 0.35
▸ TSHR P16473 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29516872 1.00 STAT3 (0.69) STAT3PTAFRCYP3A4ALDH1A1LMNA
Incensole SCHEMBL20565149 0.82 STAT3 (1.00) STAT3PTAFRCYP3A4ALDH1A1LMNA
Incensole SCHEMBL20565148 0.82 STAT3 (1.00) STAT3PTAFRCYP3A4ALDH1A1LMNA
Incensole SCHEMBL31471800 0.82 STAT3 (1.00) STAT3PTAFRCYP3A4ALDH1A1LMNA
Incensole SCHEMBL29369781 0.82 STAT3 (1.00) STAT3PTAFRCYP3A4ALDH1A1LMNA
Incensole SCHEMBL13394034 0.82 STAT3 (1.00) STAT3PTAFRCYP3A4ALDH1A1LMNA
SCHEMBL3676277 0.73 CYP3A4 (0.48) STAT3PTAFRCYP3A4ALDH1A1LMNA
SCHEMBL3676278 0.73 CYP3A4 (0.48) STAT3PTAFRCYP3A4ALDH1A1LMNA
SCHEMBL272273 0.71 CYP3A4 (0.46) STAT3PTAFRCYP3A4ALDH1A1LMNA
SCHEMBL4615726 0.71 CYP3A4 (0.46) STAT3PTAFRCYP3A4ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9278078-B2 Neuronal circuit-dependent neuroprotection by interaction between nicotinic receptors FERCHMIN PETER ANDREW (US) 2016-03-08 — — US disclosed
US-20160008315-A1 NEURONAL CIRCUIT-DEPENDENT NEUROPROTECTION BY INTERACTION BETWEEN NICOTINIC RECEPTORS FERCHMIN PETER ANDREW (US) 2016-01-14 — — US disclosed
US-20160000729-A1 NEURONAL CIRCUIT-DEPENDENT NEUROPROTECTION BY INTERACTION BETWEEN NICOTINIC RECEPTORS FERCHMIN PETER ANDREW (US) 2016-01-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160008315-A1 NEURONAL CIRCUIT-DEPENDENT NEUROPROTECTION BY INTERACTION BETWEEN NICOTINIC RECEPTORS CHRNA7, CHRNA4, CHRNA10 STAT3 2203/4885PTAFR 3303/4885CYP3A4 3021/4885
US-20160000729-A1 NEURONAL CIRCUIT-DEPENDENT NEUROPROTECTION BY INTERACTION BETWEEN NICOTINIC RECEPTORS CHRNA7, CHRNA4, CHRNA10 STAT3 2268/4885PTAFR 3011/4885CYP3A4 3366/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.