Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 1.00 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.82 |
| ▸ | TEK | Q02763 | 1/20 | 0.53 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17409452 | 0.90 | KDR (1.00) | KDRPDGFRBTEKEIF2AK2CA12 | |
| SCHEMBL17409480 | 0.85 | KDR (1.00) | KDRPDGFRBEIF2AK2 | |
| SCHEMBL17409458 | 0.83 | KDR (1.00) | KDRPDGFRB | |
| SCHEMBL17409451 | 0.78 | KDR (1.00) | KDRPDGFRB | |
| SCHEMBL17424507 | 0.77 | KDR (0.77) | KDRPDGFRB | |
| SCHEMBL17424510 | 0.75 | KDR (0.82) | KDRPDGFRB | |
| SCHEMBL16008286 | 0.73 | CA12 (0.63) | KDRPDGFRBTEKEIF2AK2CA12 | |
| SCHEMBL4718055 | 0.73 | KDR (0.61) | KDRPDGFRBTEKCA12CA1 | |
| SCHEMBL17424509 | 0.72 | KDR (0.82) | KDRPDGFRB | |
| SCHEMBL17409478 | 0.72 | KDR (1.00) | KDRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9233968-B1 | Kinase inhibitors | ALLERGAN, INC. (US) | 2016-01-12 | — | — | US | claimed |
| US-9233968-B1 | Kinase inhibitors | ALLERGAN, INC. (US) | 2016-01-12 | — | — | US | disclosed |
| US-9233968-B1 | Kinase inhibitors | ALLERGAN, INC. (US) | 2016-01-12 | — | — | US | disclosed |