Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 1.00 |
| ▸ | PDGFRB | P09619 | 13/20 | 1.00 |
| ▸ | TEK | Q02763 | 2/20 | 0.65 |
| ▸ | KIT | P10721 | 2/20 | 0.65 |
| ▸ | BRAF | P15056 | 2/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.65 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.65 |
| ▸ | FLT1 | P17948 | 1/20 | 0.65 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.65 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.52 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | BCR | P11274 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17409474 | 0.88 | KDR (1.00) | KDRPDGFRBTEKKITBRAF | |
| SCHEMBL17409454 | 0.86 | KDR (1.00) | KDRPDGFRBKITDDR1 | |
| SCHEMBL17409485 | 0.84 | KDR (1.00) | KDRPDGFRB | |
| SCHEMBL17409477 | 0.84 | KDR (1.00) | KDRPDGFRB | |
| SCHEMBL17409464 | 0.83 | KDR (1.00) | KDRPDGFRB | |
| SCHEMBL2515186 | 0.79 | KDR (1.00) | KDRPDGFRBTEKKITBRAF | |
| SCHEMBL17409459 | 0.78 | KDR (1.00) | KDRPDGFRB | |
| SCHEMBL2515438 | 0.77 | KDR (1.00) | KDRPDGFRBTEKKITBRAF | |
| SCHEMBL17595123 | 0.76 | RAF1 (0.68) | KDRPDGFRBTEKKITBRAF | |
| SCHEMBL17409494 | 0.76 | KDR (0.76) | KDRPDGFRBTEKLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9233968-B1 | Kinase inhibitors | ALLERGAN, INC. (US) | 2016-01-12 | — | — | US | claimed |
| US-9233968-B1 | Kinase inhibitors | ALLERGAN, INC. (US) | 2016-01-12 | — | — | US | disclosed |
| US-9233968-B1 | Kinase inhibitors | ALLERGAN, INC. (US) | 2016-01-12 | — | — | US | disclosed |
| US-9233968-B1 | Kinase inhibitors | ALLERGAN, INC. (US) | 2016-01-12 | — | — | US | disclosed |